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Coprelotamab
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Catalog No. T80596Cas No. 2348469-84-9
Alias GB-221
Coprelotamab (GB221) is a humanized IgG1 monoclonal antibody targeting human epidermal growth factor receptor 2 (HER2/ERBB2), which effectively blocks receptor dimerization and downstream proliferative signaling by specifically binding to the HER2 extracellular domain IV. This antibody not only disrupts the malignant cell cycle but also possesses potent antibody-dependent cellular cytotoxicity (ADCC), enabling the precise elimination of HER2-overexpressing tumor lesions by recruiting immune effector cells.
Coprelotamab
Coprelotamab
Copy Product Info😃Good
Catalog No. T80596Alias GB-221Cas No. 2348469-84-9
Coprelotamab (GB221) is a humanized IgG1 monoclonal antibody targeting human epidermal growth factor receptor 2 (HER2/ERBB2), which effectively blocks receptor dimerization and downstream proliferative signaling by specifically binding to the HER2 extracellular domain IV. This antibody not only disrupts the malignant cell cycle but also possesses potent antibody-dependent cellular cytotoxicity (ADCC), enabling the precise elimination of HER2-overexpressing tumor lesions by recruiting immune effector cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Coprelotamab (GB221) is a humanized IgG1 monoclonal antibody targeting human epidermal growth factor receptor 2 (HER2/ERBB2), which effectively blocks receptor dimerization and downstream proliferative signaling by specifically binding to the HER2 extracellular domain IV. This antibody not only disrupts the malignant cell cycle but also possesses potent antibody-dependent cellular cytotoxicity (ADCC), enabling the precise elimination of HER2-overexpressing tumor lesions by recruiting immune effector cells. |
| Synonyms | GB-221 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | EGFR2 |
| Cas No. | 2348469-84-9 |
| Isotype | IgG1 |
| Storage | store at low temperature | -20°C for 2 years, 4°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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