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Ficlatuzumab
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Catalog No. T76745 Copy Product Info
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Ficlatuzumab is a humanized monoclonal antibody that specifically targets and neutralizes the biological activity of human hepatocyte growth factor (HGF), by inhibiting HGF, Ficlatuzumab effectively blocks c-Met receptor-mediated downstream signaling pathways responsible for cancer cell proliferation, migration, and invasion, demonstrating applicable use for the treatment of squamous cell carcinoma.
Cas No. 1174900-84-5
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $147 | - | In Stock | |
| 5 mg | $446 | - | In Stock | |
| 10 mg | $762 | - | In Stock | |
| 25 mg | $1,130 | - | In Stock | |
| 50 mg | $1,530 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.0% (SDS-PAGE); 99.0% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
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| Description | Ficlatuzumab is a humanized monoclonal antibody that specifically targets and neutralizes the biological activity of human hepatocyte growth factor (HGF), by inhibiting HGF, Ficlatuzumab effectively blocks c-Met receptor-mediated downstream signaling pathways responsible for cancer cell proliferation, migration, and invasion, demonstrating applicable use for the treatment of squamous cell carcinoma. |
| In vitro | Ficlatuzumab (20 μg/mL, 24 hours) treatment of HNSCC cells can effectively reduce the migration and invasion of HNSCC cells promoted by tumor-associated fibroblast (TAF) culture medium, and can also reduce the epithelial-mesenchymal transition (EMT) and vimentin expression of HNSCC cells promoted by TAF. [1] |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | HGF/SF |
| Molecular Weight | 145.39 kDa |
| Cas No. | 1174900-84-5 |
| Isotype | IgG1 |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Ficlatuzumab chemical structure | Ficlatuzumab in vitro | Ficlatuzumab molecular weight
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