keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vasonatrin Peptide (VNP) TFA, a chimeric compound derived from atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP), exhibits venodilating properties reminiscent of CNP, natriuretic effects akin to ANP, as well as unique arterial vasodilating capabilities not characteristic of either parent peptide. Additionally, VNP TFA confers cardioprotection in diabetic ischemia-reperfusion injury by attenuating endoplasmic reticulum (ER) stress through the cGMP-PKG signaling cascade [1] [2] [3].
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Description | Vasonatrin Peptide (VNP) TFA, a chimeric compound derived from atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP), exhibits venodilating properties reminiscent of CNP, natriuretic effects akin to ANP, as well as unique arterial vasodilating capabilities not characteristic of either parent peptide. Additionally, VNP TFA confers cardioprotection in diabetic ischemia-reperfusion injury by attenuating endoplasmic reticulum (ER) stress through the cGMP-PKG signaling cascade [1] [2] [3]. |
In vitro | Vasonatrin Peptide (VNP) significantly augments both mRNA expression and protein secretion of adiponectin while concurrently inhibiting IL-6 production in mature adipocytes. Additionally, VNP notably elevates intracellular cGMP concentrations. These VNP effects can be replicated by 8-br-cGMP, but are inhibited by either HS-142-1, or KT-5823 [2]. |
In vivo | Vasonatrin peptide, administered intravenously at a dose of 100 μg/kg 10 minutes before reperfusion, mitigates myocardial ischemia-reperfusion injury in diabetic rats [3]. |
Molecular Weight | 2979.39 |
Formula | C126H199N36O38S3F3 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Vasonatrin Peptide (VNP) TFA inhibitor inhibit