m-PEG10-alcohol

Name: m-PEG10-alcohol
Brand: TargetMol
SKU: T15834
Rating: 4.5 (1 reviews)

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Catalog No. T15834Cas No. 27425-92-9

Alias Decaethylene glycol monomethyl ether

m-PEG10-alcohol, also known as Decaethylene glycol monomethyl ether, is a non-cleavable 10 unit PEG ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1]. Additionally, m-PEG10-alcohol serves as a PEG-based PROTAC linker, enabling its application in the synthesis of PROTACs[1].

m-PEG10-alcohol

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Catalog No. T15834Alias Decaethylene glycol monomethyl etherCas No. 27425-92-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	Inquiry	7-10 days	7-10 days
500 mg	Inquiry	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	m-PEG10-alcohol, also known as Decaethylene glycol monomethyl ether, is a non-cleavable 10 unit PEG ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1]. Additionally, m-PEG10-alcohol serves as a PEG-based PROTAC linker, enabling its application in the synthesis of PROTACs[1].
In vitro	ADCs, or antibody-drug conjugates, consist of an antibody that is linked to a cytotoxic drug molecule via a specialized linker. This allows the antibody to specifically target certain cells or proteins, while the attached cytotoxin can selectively destroy those targeted cells. PROTACs, or proteolysis-targeting chimeras, are composed of two distinct ligands joined by a linker. One of these ligands binds to a specific protein target, while the other binds to an E3 ubiquitin ligase. When the PROTAC binds to both the target protein and the E3 ligase, it triggers the ubiquitin-proteasome system within cells to degrade the target protein, thereby providing a mechanism for targeted protein degradation.
Synonyms	Decaethylene glycol monomethyl ether

Chemical Properties

Molecular Weight	472.57
Formula	C₂₁H₄₄O₁₁
Cas No.	27425-92-9
Smiles	C(OCCOCCOCCOCCOCCO)COCCOCCOCCOCCOC
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc