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Cryogenine
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Catalog No. T38327Cas No. 10308-13-1
Cryogenine is an alkaloid originally isolated from H. salicifolia that exhibits anti-inflammatory activity. It inhibits prostaglandin synthetase (IC50 = 424 μM) and, at a dosage of 100 mg/kg per day (p.o.), reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.
Cryogenine
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Catalog No. T38327Cas No. 10308-13-1
Cryogenine is an alkaloid originally isolated from H. salicifolia that exhibits anti-inflammatory activity. It inhibits prostaglandin synthetase (IC50 = 424 μM) and, at a dosage of 100 mg/kg per day (p.o.), reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $555 | 35 days | 35 days | |
| 5 mg | $2,470 | 35 days | 35 days | |
| 10 mg | $3,970 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | Cryogenine is an alkaloid originally isolated from H. salicifolia that exhibits anti-inflammatory activity. It inhibits prostaglandin synthetase (IC50 = 424 μM) and, at a dosage of 100 mg/kg per day (p.o.), reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis. |
| Molecular Weight | 435.52 |
| Formula | C26H29NO5 |
| Cas No. | 10308-13-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMF: 30 mg/mL (68.88 mM), Sonication is recommended. DMSO: 30 mg/mL (68.88 mM), Sonication is recommended. DMSO:PBS (pH 7.2) (1:3): 0.25 mg/mL (0.57 mM), Sonication is recommended. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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