This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
IDO/Tubulin-IN-2
Catalog No. T74536 CAS
2409479-24-7
IDO/Tubulin-IN-2 (HT2) is a powerful inhibitor of both TDO and tubulin. This compound demonstrates significant efficacy against various cancer cell lines, including U87, HepG2, A549, HCT-116, and LO2, with respective IC50 values of 0.43, 0.036, 0.041, 0.095, and 1.04 μM. Additionally, IDO/Tubulin-IN-2 markedly enhances antitumor activity [1].
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage
& Solubility Information
Description
IDO/Tubulin-IN-2 (HT2) is a powerful inhibitor of both TDO and tubulin. This compound demonstrates significant efficacy against various cancer cell lines, including U87, HepG2, A549, HCT-116, and LO2, with respective IC50 values of 0.43, 0.036, 0.041, 0.095, and 1.04 μM. Additionally, IDO/Tubulin-IN-2 markedly enhances antitumor activity [1].
In vitro
IDO/Tubulin-IN-2 (HT2) (0-50 μM, 4 h) exhibits potent cytotoxicity, with IC50 values ranging from 0.036 to 0.43 μM against various cancer cell lines [1]. At a concentration of 0.1 μM over 24 h, it predominantly arrests the cell cycle of HepG2 cells in the G2 phase [1], induces apoptosis [1], and significantly promotes proteolytic cleavage of PARP as well as up-regulates caspase-3 expression [1]. Additionally, at 0.05 μM, IDO/Tubulin-IN-2 progressively reduces TDO mRNA expression levels in a time-dependent manner over 24, 48, and 72 h [1]. After 2 days, it augments T-cell activation and proliferation, thereby enhancing the immune response [1].
In vivo
IDO/Tubulin-IN-2 (HT2), administered intravenously at a dosage of 30 mg/kg daily for 21 days, considerably suppresses tumor proliferation [1]. Additionally, when given for 29 days using the same dosage and route, it effectively enhances antitumor immunity, thereby augmenting the therapeutic effectiveness against tumors [1].
Molecular Weight
860.87
Formula
C48H40N6O10
CAS No.
2409479-24-7
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
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Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.