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Martynoside

Name: Martynoside
Brand: TargetMol
SKU: TMA0424
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TMA0424Cas No. 67884-12-2

Martynoside is an active glycoside extracted from Rehmannia, with anti-estrogen, anticancer, cytotoxic, hematopoietic, antioxidant, and anti-metastatic properties. It increases IGFBP3 levels through the ER pathway.

Martynoside

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Purity: 99.83%

Catalog No. TMA0424Cas No. 67884-12-2

Pack Size	Price	Availability
1 mg	$129	In Stock
5 mg	$372	In Stock
10 mg	$596	In Stock
25 mg	$933	In Stock
50 mg	$1,250	In Stock

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Purity:99.83%

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COA HPLC

Product Introduction

Bioactivity

Description	Martynoside is an active glycoside extracted from Rehmannia, with anti-estrogen, anticancer, cytotoxic, hematopoietic, antioxidant, and anti-metastatic properties. It increases IGFBP3 levels through the ER pathway.
In vitro	Martynoside attenuated 5-FU-induced cytotoxicity of bone marrow nucleated cells, increased the stability of RPL27A protein, and reduced RPL27A ubiquitination at lys92 (K92) and lys94 (K94) sites. [1] Martynoside(50 μg/ml) protects isolated bone marrow cells from 5-fluorouracil (5-FU) -induced cell death and inflammation by down-regulating the TNF signaling pathway. [2]
In vivo	Martynoside 10 mg/kg daily and receiving exercise for 5 weeks was found to have the potential to antagonize exercise anemia, and the mechanism of this effect may be related to preventing free radical damage to red blood cells. [3]

Chemical Properties

Molecular Weight	652.64
Formula	C₃₁H₄₀O₁₅
Cas No.	67884-12-2
Smiles	O([C@H]1[C@H](OC(/C=C/C2=CC(OC)=C(O)C=C2)=O)[C@@H](CO)O[C@@H](OCCC3=CC(O)=C(OC)C=C3)[C@@H]1O)[C@H]4[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O4
Relative Density.	1.48g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16 mg/mL (24.52 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5322 mL	7.6612 mL	15.3224 mL	76.6119 mL
5 mM	0.3064 mL	1.5322 mL	3.0645 mL	15.3224 mL
10 mM	0.1532 mL	0.7661 mL	1.5322 mL	7.6612 mL
20 mM	0.0766 mL	0.3831 mL	0.7661 mL	3.8306 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc