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HBV-IN-25

Catalog No. T61115 CAS 2161364-69-6

HBV-IN-25 is a novel chemical compound that acts as a potent HBV cccDNA reducer when administered orally. It exhibits significant anti-HBeAg potency and anti-HBV activity, with IC50 values of 0.58 μM and 1.15 μM, respectively. Moreover, HBV-IN-25 demonstrates favorable aqueous solubility (LYSA>452 μg/mL) and no cellular toxicity, making it a promising candidate for further investigation and development [1].

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HBV-IN-25, CAS 2161364-69-6

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	HBV-IN-25 is a novel chemical compound that acts as a potent HBV cccDNA reducer when administered orally. It exhibits significant anti-HBeAg potency and anti-HBV activity, with IC50 values of 0.58 μM and 1.15 μM, respectively. Moreover, HBV-IN-25 demonstrates favorable aqueous solubility (LYSA＞452 μg/mL) and no cellular toxicity, making it a promising candidate for further investigation and development [1].
In vitro	HBV-IN-25, at concentrations ranging from 8-50 μM over a period of 5 days, exhibits anti-HBeAg potency, demonstrated by an IC50 value of 0.58 μM. Additionally, its anti-HBV activity in primary human hepatocytes (PHH) remains consistent or shows a slight decrease, with an IC50 value of 1.15 μM [1].
In vivo	HBV-IN-25, administered orally at doses of 5, 20, 100, and 300 mg/kg, exhibits favorable pharmacokinetic (PK) attributes and demonstrates remarkable effectiveness in markedly lowering levels of HBV antigens, DNA, and intrahepatic cccDNA as evidenced in the HBVcircle mouse model. The pharmacokinetic parameters for each dosage showed a proportional increase in both maximum concentration (C max) and area under the curve (AUC), indicating significant drug absorption and sustained presence in the system. Furthermore, dose-dependent effects were observed in terminal body weight changes, spinal cord inflammation, demyelination, and the count of apoptotic cells in spinal cord sections, thereby underscoring the compound’s efficacy and potential therapeutic implications.

Molecular Weight	343.76
Formula	C18H14ClNO4
CAS No.	2161364-69-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HBV-IN-25 2161364-69-6 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.