Antimalarial agent 37 (compound 33), a selective Type Ⅱ kinase inhibitor, exhibits antiplasmodial activity and demonstrates cytotoxicity towards HepG2 and MCF 7 cancer cells [1].

Antimalarial agent 37 (0-50 nM, 72 h) exhibits activity against the malaria parasite, possessing EC50 values of 31 nM and 35 nM for strains Dd2 and 3D7 respectively [1]. In mouse liver microsomes, this compound shows microsomal stability with a half-life of 41.4 minutes and a clearance rate of 17 μL/min/mg [1]. Additionally, Antimalarial agent 37 (0-5000 nM, 48 h) demonstrates cytotoxicity in HepG2 and MCF7 cells, with EC50 values of 2850 nM and 3540 nM respectively, and selectivity indices of 92 and 114 [1].