This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
CHIKV-IN-3
Catalog No. T61675
CHIKV-IN-3 is a potent inhibitor effective against two low-passage CHIKV strains, demonstrating EC50 values of 1.55 μM for CHIKV-122508 and 0.14 μM for CHIKV-6708, respectively. It operates by targeting host cells to disrupt viral replication, while maintaining a minimal cytotoxic liability (CC50 < 100 μM). Additionally, CHIKV-IN-3 has shown a prophylactic effect [1].
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage
& Solubility Information
Description
CHIKV-IN-3 is a potent inhibitor effective against two low-passage CHIKV strains, demonstrating EC50 values of 1.55 μM for CHIKV-122508 and 0.14 μM for CHIKV-6708, respectively. It operates by targeting host cells to disrupt viral replication, while maintaining a minimal cytotoxic liability (CC50 > 100 μM). Additionally, CHIKV-IN-3 has shown a prophylactic effect [1].
In vitro
CHIKV-IN-3 (compound (E)-42; HeLa CCL2 cells; 0.1-100 μM; 24 hours) inhibits the Chikungunya virus (CHIKV) replication with an EC 50 of 1.55 μM and demonstrates low cytotoxicity ( CC 50 =129.6 μM) [1]. CHIKV-IN-3 (HeLa CCL2 cells; 20, 40, 80 μM; 24 hours) shows the highest degree of inhibition with approximately 3.9-log reduction in viral titre (ca. 99.99% inhibition) at 80 μM [1]. Cell Cytotoxicity Assay [1] Cell Line: HeLa CCL2 cells, HeLa CCL2 cells infected with CHIKV-122508 Concentration: 0.1-100 μM Incubation Time: 24 hours Result: Inhibited the CHIKV replication with an EC 50 of 1.55 μM and demonstrated low cytotoxicity( CC 50 =129.6 μM)
Molecular Weight
383.95
Formula
C24H30ClNO
Storage
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
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Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.