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Mutanocyclin
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Catalog No. T79931Cas No. 875455-92-8
Mutanocyclin, a powerful antifungal agent, inhibits the filamentation of Candida albicans (C. albicans) and decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1. Furthermore, it suppresses the yeast-form in ex vivo mouse [1].
Mutanocyclin
Copy Product Info😃Good
Catalog No. T79931Cas No. 875455-92-8
Mutanocyclin, a powerful antifungal agent, inhibits the filamentation of Candida albicans (C. albicans) and decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1. Furthermore, it suppresses the yeast-form in ex vivo mouse [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
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| 5 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Storage & Solubility Information
| Description | Mutanocyclin, a powerful antifungal agent, inhibits the filamentation of Candida albicans (C. albicans) and decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1. Furthermore, it suppresses the yeast-form in ex vivo mouse [1]. |
| In vitro | Mutanocyclin, at concentrations of 8, 16, and 32 µg/mL over 24 and 36 hours, dose-dependently inhibits the filamentation of Candida albicans (C. albicans) [1]. At a concentration of 32 µg/mL, Mutanocyclin reduces the mRNA expression of HWP1, ECE1, FLO8, and TEC1 in C. albicans cells [1]. The compound functions by modulating the PKA pathway, specifically by degrading the catalytic subunit Tpk2 and preferentially targeting its binding partner Sfl1 [1]. |
| In vivo | Mutanocyclin (32 µg/mL; 24-hour exposure) inhibits the yeast form of C. albicans in an ex vivo murine tongue infection model [1] and, at concentrations of 6.4, 12.8, and 25.6 µg/mL over 48 hours, attenuates the virulence of C. albicans in a G. mellonella infection model [1]. |
| Molecular Weight | 197.23 |
| Formula | C10H15NO3 |
| Cas No. | 875455-92-8 |
| Smiles | C(C)(=O)C=1C(=O)[C@@H](CC(C)C)NC1O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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