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Mutanocyclin

Name: Mutanocyclin
Brand: TargetMol
SKU: T79931
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T79931 Copy Product Info

Purity: 99.99%

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Mutanocyclin, as a potent antifungal agent, can inhibit the filamentation of Candida albicans and downregulate the mRNA expression levels of HWP1, ECE1, FLO8 and TEC1 genes. In addition, Mutanocyclin can also effectively inhibit yeast morphogenesis in an in vitro mouse model.

Cas No. 875455-92-8

Pack Size	Price	USA Stock	Global Stock
1 mg	$52	-	In Stock
5 mg	$123	-	In Stock
10 mg	$198	-	In Stock
25 mg	$347	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.99%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Mutanocyclin, as a potent antifungal agent, can inhibit the filamentation of Candida albicans and downregulate the mRNA expression levels of HWP1, ECE1, FLO8 and TEC1 genes. In addition, Mutanocyclin can also effectively inhibit yeast morphogenesis in an in vitro mouse model.
In vitro	Methods: Candida albicans was treated with mutanocyclin at concentrations of 8, 16, and 32 µg/mL for 24 and 36 hours, respectively. Results: Mutanocyclin inhibited the filamentation of Candida albicans in a dose‑dependent manner. Methods: Candida albicans was treated with mutanocyclin at 32 µg/mL. Results: Mutanocyclin downregulated the mRNA expression levels of HWP1, ECE1, FLO8, and TEC1 in Candida albicans cells. Methods: Relevant assays and analyses were performed to investigate the mechanism of action of mutanocyclin against Candida albicans. Results: Mutanocyclin exerted its antifungal effect by regulating the PKA catalytic subunit Tpk2 and its preferred binding target Sfl1[1].
In vivo	Methods: An ex vivo mouse tongue infection model was used. Mouse tongues infected for 24 hours were treated with mutanocyclin (32 µg/mL). Results: Mutanocyclin inhibited the yeast form of Candida albicans. Methods: In a Galleria mellonella infection model, larvae were treated with mutanocyclin (6.4, 12.8, 25.6 µg/mL) for 48 hours. Results: Mutanocyclin attenuated the virulence of Candida albicans[1].

Chemical Properties

Molecular Weight	197.23
Formula	C₁₀H₁₅NO₃
Cas No.	875455-92-8
Smiles	C(C)(=O)C=1C(=O)[C@@H](CC(C)C)NC1O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (202.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0702 mL	25.3511 mL	50.7022 mL	253.5111 mL
5 mM	1.0140 mL	5.0702 mL	10.1404 mL	50.7022 mL
10 mM	0.5070 mL	2.5351 mL	5.0702 mL	25.3511 mL
20 mM	0.2535 mL	1.2676 mL	2.5351 mL	12.6756 mL
50 mM	0.1014 mL	0.5070 mL	1.0140 mL	5.0702 mL
100 mM	0.0507 mL	0.2535 mL	0.5070 mL	2.5351 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.