Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mutanocyclin, a powerful antifungal agent, inhibits the filamentation of Candida albicans (C. albicans) and decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1. Furthermore, it suppresses the yeast-form in ex vivo mouse [1].
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Description | Mutanocyclin, a powerful antifungal agent, inhibits the filamentation of Candida albicans (C. albicans) and decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1. Furthermore, it suppresses the yeast-form in ex vivo mouse [1]. |
In vitro | Mutanocyclin, at concentrations of 8, 16, and 32 µg/mL over 24 and 36 hours, dose-dependently inhibits the filamentation of Candida albicans (C. albicans) [1]. At a concentration of 32 µg/mL, Mutanocyclin reduces the mRNA expression of HWP1, ECE1, FLO8, and TEC1 in C. albicans cells [1]. The compound functions by modulating the PKA pathway, specifically by degrading the catalytic subunit Tpk2 and preferentially targeting its binding partner Sfl1 [1]. |
In vivo | Mutanocyclin (32 µg/mL; 24-hour exposure) inhibits the yeast form of C. albicans in an ex vivo murine tongue infection model [1]. At concentrations of 6.4, 12.8, and 25.6 µg/mL over 48 hours, mutanocyclin attenuates the virulence of C. albicans in a G. mellonella infection model [1]. |
Molecular Weight | 197.23 |
Formula | C10H15NO3 |
CAS No. | 875455-92-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Mutanocyclin 875455-92-8 inhibitor inhibit