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CC-90002
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Catalog No. T76732Cas No. 2085844-54-6
Alias CC90002, CC 90002
CC-90002 is a humanized monoclonal antibody targeting CD47 that inhibits CD47-SIRPα interactions, suitable for studying hematologic malignancies such as leukemia.
CC-90002
CC-90002
😃Good
Purity: 95%
Catalog No. T76732Alias CC90002, CC 90002Cas No. 2085844-54-6
CC-90002 is a humanized monoclonal antibody targeting CD47 that inhibits CD47-SIRPα interactions, suitable for studying hematologic malignancies such as leukemia.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | - | In Stock | |
| 5 mg | $619 | - | In Stock | |
| 10 mg | $993 | - | In Stock | |
| 25 mg | $1,470 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:95.8% (SDS-PAGE); 95.4% (SEC-HPLC)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
| Description | CC-90002 is a humanized monoclonal antibody targeting CD47 that inhibits CD47-SIRPα interactions, suitable for studying hematologic malignancies such as leukemia. |
| In vitro | CC-90002 exhibits high affinity for CD47, with a Kd value reaching the sub-nanomolar range [1]. CC-90002 blocks the interaction between CD47 and SIRPα, with an IC50 value in the sub-nanomolar range [1]. CC-90002 demonstrates concentration-dependent inhibitory activity against acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) cell lines [1]. |
| In vivo | CC-90002 exhibits significant dose-dependent antitumor activity and achieves marked tumor regression in tumor xenograft models [1]. |
| Synonyms | CC90002, CC 90002 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | CD47 |
| Molecular Weight | 146.53 kDa |
| Cas No. | 2085844-54-6 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG4 kappa |
| Recommended Isotype Control |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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