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DL-Willardiine
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Catalog No. T50094Cas No. 19772-76-0
Alias 2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid
DL-Willardiine (2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid) is an unnatural amino acid, a derivative of glutamate. It is an agonist of mGluR5, which regulates the activity of enzymes involved in neurotransmitter synthesis and catabolism, and affects the activity of ion channels and other membrane proteins.
DL-Willardiine
Copy Product Info🥰Excellent
Purity: 99.99%
Catalog No. T50094Alias 2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acidCas No. 19772-76-0
DL-Willardiine (2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid) is an unnatural amino acid, a derivative of glutamate. It is an agonist of mGluR5, which regulates the activity of enzymes involved in neurotransmitter synthesis and catabolism, and affects the activity of ion channels and other membrane proteins.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $86 | In Stock | In Stock | |
| 2 mg | $129 | In Stock | In Stock | |
| 5 mg | $198 | In Stock | In Stock | |
| 10 mg | $298 | In Stock | In Stock | |
| 25 mg | $475 | In Stock | In Stock | |
| 50 mg | $672 | In Stock | In Stock | |
| 100 mg | $912 | In Stock | In Stock | |
| 200 mg | $1,190 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.99%
Appearance:Solid
Color:White
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Product Introduction
DL-Willardiine AI Summary
DL-Willardiine exhibits several notable bioactivities. It has a protolysis constant at an ionic strength of 0.1 M with a pKa of 9.3. At a concentration of 100 µM, the compound shows 100% inhibition of specific [3H]AMPA binding to rat brain ionotropic glutamate receptor AMPA membranes. It possesses an IC50 value of 1800.0 nM for inhibiting [3H]AMPA binding and an IC50 value of 97000.0 nM for inhibiting [3H]kainate binding to the respective ionotropic receptors in rat brain membranes. In assays using Sf9 cells, DL-Willardiine demonstrates varying affinities for ionotropic glutamate receptors subtypes, with Ki values of 410.0 nM for iGluR1, 1220.0 nM for iGluR2(R), 14200.0 nM for iGluR4, 19000.0 nM for iGluR3, and significantly lower affinities for iGluR5(Q)1b and iGluR6(V,C,R) subtypes. Additionally, DL-Willardiine acts as an inhibitor of Bloom's syndrome helicase (BLM), with an observed potency of 63,095.7 nM in related assays. These properties indicate the compound's potential roles in modulating glutamatergic neurotransmission and functioning as a BLM inhibitor..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | DL-Willardiine (2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid) is an unnatural amino acid, a derivative of glutamate. It is an agonist of mGluR5, which regulates the activity of enzymes involved in neurotransmitter synthesis and catabolism, and affects the activity of ion channels and other membrane proteins. |
| Synonyms | 2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid |
| Molecular Weight | 199.16 |
| Formula | C7H9N3O4 |
| Cas No. | 19772-76-0 |
| Smiles | C(C(C(O)=O)N)N1C(=O)NC(=O)C=C1 |
| Relative Density. | 1.501 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: < 1.99 mg/mL (10 mM, insoluble or slightly soluble)  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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