Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active inhibitor of lipoxygenase. Masoprocol exhibits antihyperglycemic activity that has the potential for the type II diabetes research. In vivo, Masoprocol reduces the concentration of glucose and hepatic triglyceride [1] [2] [3].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 166.00 | |
25 mg | 6-8 weeks | $ 885.00 | |
50 mg | 6-8 weeks | $ 1,150.00 | |
100 mg | 6-8 weeks | $ 1,740.00 |
Description | Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active inhibitor of lipoxygenase. Masoprocol exhibits antihyperglycemic activity that has the potential for the type II diabetes research. In vivo, Masoprocol reduces the concentration of glucose and hepatic triglyceride [1] [2] [3]. |
In vitro | Masoprocol (30 μM; 90 min) shows high basal and insulin-stimulated glucose clearance in adipocytes [2]. |
In vivo | Masoprocol, administered at 150 mg/kg orally twice a day for 12 days, exhibits antihyperglycemic effects by lowering plasma glucose levels in male C57BL/ks-db/db mice [1]. At a dosage of 0.83 mmol/kg administered twice daily for four days, it significantly decreases glucose concentrations by an average of 35% and triglyceride levels by 80% compared to controls in a rat model of type II diabetes [2]. Additionally, when given orally at doses between 40-80 mg/kg twice daily for 8 days, Masoprocol substantially reduces hepatic triglyceride secretion (P<.01) and liver triglyceride content in nondiabetic rats with diet-induced hypertriglyceridemia (HTG) [3]. |
Molecular Weight | 302.36 |
Formula | C18H22O4 |
CAS No. | 27686-84-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Masoprocol 27686-84-6 inhibitor inhibit