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Masoprocol

🥰Excellent
Catalog No. T60692Cas No. 27686-84-6
Alias meso-Nordihydroguaiaretic acid, meso-NDGA

Masoprocol (meso-Nordihydroguaiaretic acid) is a potent, orally active lipoxygenase inhibitor that exhibits antihyperglycemic activity, making it potentially valuable for type II diabetes research. In vivo, Masoprocol reduces glucose and hepatic triglyceride concentrations [1] [2] [3].

Masoprocol

Masoprocol

🥰Excellent
Purity: 99.76%
Catalog No. T60692Alias meso-Nordihydroguaiaretic acid, meso-NDGACas No. 27686-84-6
Masoprocol (meso-Nordihydroguaiaretic acid) is a potent, orally active lipoxygenase inhibitor that exhibits antihyperglycemic activity, making it potentially valuable for type II diabetes research. In vivo, Masoprocol reduces glucose and hepatic triglyceride concentrations [1] [2] [3].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$99-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.76%
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Product Introduction

Bioactivity
Description
Masoprocol (meso-Nordihydroguaiaretic acid) is a potent, orally active lipoxygenase inhibitor that exhibits antihyperglycemic activity, making it potentially valuable for type II diabetes research. In vivo, Masoprocol reduces glucose and hepatic triglyceride concentrations [1] [2] [3].
In vitro
Masoprocol (30 μM; 90 min) treatment of adipocytes showed elevated basal and insulin-stimulated glucose clearance in adipocytes [2].
In vivo
METHODS: Masoprocol (10-80 mg/kg, orally, twice daily for 4-8 days) was administered to rats fed fructose to determine whether Masoprocol could also reduce TG concentrations in rats with fructose-induced hypertriglyceridemia (HTG).
RESULTS: Masoprocol administration to rats with fructose-induced HTG resulted in a decrease in serum TG levels, a decrease in hepatic TG secretion, and an increase in peripheral TG clearance. [3]
Synonymsmeso-Nordihydroguaiaretic acid, meso-NDGA
Chemical Properties
Molecular Weight302.37
FormulaC18H22O4
Cas No.27686-84-6
SmilesC([C@@H]([C@@H](CC1=CC(O)=C(O)C=C1)C)C)C2=CC(O)=C(O)C=C2
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (264.59 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.91 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3072 mL16.5360 mL33.0721 mL165.3603 mL
5 mM0.6614 mL3.3072 mL6.6144 mL33.0721 mL
10 mM0.3307 mL1.6536 mL3.3072 mL16.5360 mL
20 mM0.1654 mL0.8268 mL1.6536 mL8.2680 mL
50 mM0.0661 mL0.3307 mL0.6614 mL3.3072 mL
100 mM0.0331 mL0.1654 mL0.3307 mL1.6536 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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