Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EGFR/HER2-IN-7 is a highly selective and potent anticancer compound specifically designed to target MCF-7 breast cancer cells. It functions as a dual inhibitor, targeting both EGFR/HER2 kinases and DHFR (dihydrofolate reductase). Its inhibitory activities are measured with IC50 values of 0.18 μM for EGFR, 0.146 μM for HER2, and 0.907 μM for DHFR [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,520.00 | |
50 mg | 10-14 weeks | $ 1,980.00 | |
100 mg | 10-14 weeks | $ 2,500.00 |
Description | EGFR/HER2-IN-7 is a highly selective and potent anticancer compound specifically designed to target MCF-7 breast cancer cells. It functions as a dual inhibitor, targeting both EGFR/HER2 kinases and DHFR (dihydrofolate reductase). Its inhibitory activities are measured with IC50 values of 0.18 μM for EGFR, 0.146 μM for HER2, and 0.907 μM for DHFR [1]. |
In vitro | EGFR/HER2-IN-7 (compound 27) exhibits significant cytotoxic effectiveness across a wide spectrum, with an IC 50 of 10.81 μM against MCF-7 breast cancer cells and demonstrates anti-breast cancer properties, registering an IC 50 of 8.29 μM after 72 hours. A Cell Viability Assay revealed that, at concentrations up to 1 mM and after an incubation period of 72 hours, EGFR/HER2-IN-7 hindered the growth of various cancer cell lines including HepG2 hepatocellular carcinoma, MCF-7 breast cancer, HCT-116 colorectal carcinoma, PC-3 prostate, and HeLa cervical epithelioid carcinoma, with IC 50 values of 10.81 μM, 8.29 μM, 13.78 μM, 16.63 μM, and 7.63 μM, respectively. Furthermore, in a Cell Cytotoxicity Assay involving the normal healthy cell line WI-38 (fetal lung fibroblast cells) and under similar experimental conditions, EGFR/HER2-IN-7 displayed low cytotoxicity with high IC 50 values, indicating a selective action towards cancer cells over healthy cells. |
Molecular Weight | 355.45 |
Formula | C19H21N3O2S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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EGFR/HER2-IN-7 inhibitor inhibit