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SJF620 hydrochloride

Catalog No. T74002 CAS 2821938-05-8

SJF620 hydrochloride is a PROTAC that utilizes a lenalidomide analog to recruit CRBN and ligands to target Btk, exhibiting a DC50 of 7.9 nM [1].

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SJF620 hydrochloride, CAS 2821938-05-8

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Biological Description

Chemical Properties

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Description	SJF620 hydrochloride is a PROTAC that utilizes a lenalidomide analog to recruit CRBN and ligands to target Btk, exhibiting a DC50 of 7.9 nM [1].
In vitro	SJF620 hydrochloride functions as a proteolysis-targeting chimera (PROTAC), effectively inducing the degradation of Bruton’s tyrosine kinase (BTK) in cellular assays. It achieves this with a degradation concentration 50 (DC50) of 7.9 nM in the NAMALWA Burkitt lymphoma cell line [1].
In vivo	SJF620 hydrochloride demonstrates an excellent pharmacokinetic profile in mice at a dose of 1 mg/kg intravenously, featuring a half-life (t 1/2) of 1.64 hours. Notably, SJF620's pharmacokinetic parameters are significantly superior to those of MT802 [1].

Molecular Weight	797.3
Formula	C41H45ClN8O7
CAS No.	2821938-05-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Related Products

Related compounds with same targets

PTD10 GBD-9 Pomalidomid-C6-PEG3-butyl-N3 PROTAC-O4I2 PROTAC BTK Degrader-3 BT-PROTAC A1874 PF15

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Keywords

SJF620 hydrochloride 2821938-05-8 PROTAC PROTACs inhibitor inhibit

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