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AM-6538
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Catalog No. T37897Cas No. 1245626-00-9
AM6538, a long-acting, high-affinity, and pseudo-irreversible cannabinoid antagonist structurally analogous to rimonabant, is a valuable tool for assessing the apparent efficacy of cannabinoid partial and full agonists. It also holds potential for future investigations requiring temporary reductions in cannabinoid receptor availability[1].
AM-6538
Copy Product Info😃Good
Catalog No. T37897Cas No. 1245626-00-9
AM6538, a long-acting, high-affinity, and pseudo-irreversible cannabinoid antagonist structurally analogous to rimonabant, is a valuable tool for assessing the apparent efficacy of cannabinoid partial and full agonists. It also holds potential for future investigations requiring temporary reductions in cannabinoid receptor availability[1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,400 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $1,820 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AM6538, a long-acting, high-affinity, and pseudo-irreversible cannabinoid antagonist structurally analogous to rimonabant, is a valuable tool for assessing the apparent efficacy of cannabinoid partial and full agonists. It also holds potential for future investigations requiring temporary reductions in cannabinoid receptor availability[1]. |
| In vitro | AM6538 acts as a cannabinoid antagonist, targeting CB1 receptors within HEK-293 cells, exhibiting wash-resistant binding properties[1]. |
| In vivo | AM6538 (1~10 mg/kg) effectively antagonizes the antinociceptive effects of cannabinoid agonists in mice[1], with 10 mg/kg indicating partial recovery of AM4054 effects. It decreases tau values for all cannabinoid agonists dose-dependently, reducing receptor availability and exerting lasting antagonism, significantly affecting tetrahydrocannabinol dose-effect function up to 7 days post-treatment[1]. |
| Molecular Weight | 542.41 |
| Formula | C26H25Cl2N5O4 |
| Cas No. | 1245626-00-9 |
| Smiles | Cc1c(nn(c1-c1ccc(cc1)C#CCCO[N+]([O-])=O)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 |
| Relative Density. | 1.37 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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