Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cap-dependent endonuclease-IN-26, a potent inhibitor of cap-dependent endonuclease (CEN) with an IC50 of 286 nM, exhibits significant antiviral activity against a broad spectrum of influenza A and B strains [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Cap-dependent endonuclease-IN-26, a potent inhibitor of cap-dependent endonuclease (CEN) with an IC50 of 286 nM, exhibits significant antiviral activity against a broad spectrum of influenza A and B strains [1]. |
In vitro | Cap-dependent endonuclease-IN-26 (compound 2v) demonstrates a wide antiviral spectrum, effective against various influenza strains, including H1N1 and H3N2, as well as oseltamivir-resistant and clinically isolated strains. Notably, it is active against the H1N1 strains (rgA/WSN/33, rgA/WSN/33-NA/H274Y, A/PR/8/34), H3N2 strains (A/Victoria/3/75, A/HongKong/8/68), and influenza B strains (Hong Kong/5/72, Maryland/1/59), with half-maximal effective concentration (EC50) values of 165.1 nM, 80.4 nM, 183.0 nM, 828.8 nM, 301.5 nM, 124.3 nM, and 176.0 nM, respectively [1]. |
In vivo | In rats, Cap-dependent endonuclease-IN-26 (compound 2v) demonstrates favorable in vivo clearance rates at 10.9 mL/min/kg [1]. Furthermore, when administered intravenously at doses ranging from 0.08-10 mg/kg once daily for a day in a mouse influenza B (B/Maryland/1/59) model, compound 2v exhibits dose-dependent efficacy in an immediate treatment scenario [1]. |
Molecular Weight | 389.45 |
Formula | C23H23N3O3 |
CAS No. | 1370238-26-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Cap-dependent endonuclease-IN-26 1370238-26-8 inhibitor inhibit