Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Xanthine oxidase-IN-5, a powerful and orally active inhibitor of xanthine oxidase (XO), exhibits an IC50 value of 0.70 μM. It possesses favorable drug-like characteristics, with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Moreover, Xanthine oxidase-IN-5 showcases significant hypouricemic effects in a hyperuricemic rat model [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Xanthine oxidase-IN-5, a powerful and orally active inhibitor of xanthine oxidase (XO), exhibits an IC50 value of 0.70 μM. It possesses favorable drug-like characteristics, with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Moreover, Xanthine oxidase-IN-5 showcases significant hypouricemic effects in a hyperuricemic rat model [1]. |
In vivo | Xanthine oxidase-IN-5 (compound 9m) effectively reduces serum uric acid levels when administered orally at a dosage of 20 mg/kg in a potassium oxonate-induced hyperuricemic rat model [1]. This single dose demonstrates significant hypouricemic effects, as observed in the measurements of serum uric acid from 0.5 to 8 hours post-administration. |
Molecular Weight | 341.34 |
Formula | C18H16FN3O3 |
CAS No. | 2276711-87-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Xanthine oxidase-IN-5 2276711-87-4 inhibitor inhibit