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Ara-G is a deoxyguanosine (GdR) analog and a nucleoside analogue that is rapidly converted by cells of the T lymphoid lineage to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and selective in vitro toxicity to T lymphoblastoid cell lines as well as to freshly isolated leukemia cells from patients with T cell acute lymphoblastic leukemia (ALL).
Pack Size | Price | Availability | Quantity |
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25 mg | $31 | In Stock | |
50 mg | $41 | In Stock | |
100 mg | $66 | In Stock |
Description | Ara-G is a deoxyguanosine (GdR) analog and a nucleoside analogue that is rapidly converted by cells of the T lymphoid lineage to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and selective in vitro toxicity to T lymphoblastoid cell lines as well as to freshly isolated leukemia cells from patients with T cell acute lymphoblastic leukemia (ALL). |
In vitro | Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into the DNA.3,1 Ara-G inhibits DNA replication by 92% after 30 minutes when used at a concentration of 50 μM in CEM cells, which are used as a model for human T lymphoblasts.1 It also halts the cell cycle at the sub-G1 phase and induces apoptosis in CEM cells.3 Syngeneic bone marrow containing 6C3HED tumor cells treated with ara-G (100 mM) ex vivo prior to transplantation increases survival of lethally irradiated mice and induces reconstitution of lymphoid, myeloid, and erythroid cell linages.4 |
Molecular Weight | 283.24 |
Formula | C10H13N5O5 |
Cas No. | 38819-10-2 |
Smiles | Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O |
Relative Density. | 2.25 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: Partially Soluble DMF: 3 mg/mL (10.59 mM), Sonication is recommended. DMSO: 55 mg/mL (194.18 mM), Sonication is recommended. ![]() PBS (pH 7.2): 0.3 mg/mL (1.06 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||||||||||||
PBS (pH 7.2)/DMF/DMSO
DMF/DMSO
DMSO
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