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IdeS Protein, Streptococcus pyogenes, Recombinant (His)

Catalog No. TMPY-06023

IdeS (IgG-degrading enzyme of Streptococcus pyogenes) is a secreted cysteine endopeptidase from the human pathogen S. pyogenes with an extraordinarily high degree of substrate specificity, catalyzing a single proteolytic cleavage at the lower hinge of human IgG. This proteolytic degradation promotes inhibition of opsonophagocytosis and interferes with the killing of group A Streptococcus. IdeS Protein, Streptococcus pyogenes, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 36.2 kDa and the accession number is F8V4V0-1.

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IdeS Protein, Streptococcus pyogenes, Recombinant (His)
Pack Size Availability Price/USD Quantity
100 μg 5 days $ 600.00
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Biological Description
Technical Params
Product Properties
Description IdeS (IgG-degrading enzyme of Streptococcus pyogenes) is a secreted cysteine endopeptidase from the human pathogen S. pyogenes with an extraordinarily high degree of substrate specificity, catalyzing a single proteolytic cleavage at the lower hinge of human IgG. This proteolytic degradation promotes inhibition of opsonophagocytosis and interferes with the killing of group A Streptococcus. IdeS Protein, Streptococcus pyogenes, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 36.2 kDa and the accession number is F8V4V0-1.
Species Streptococcus pyogenes
Expression System E. coli
Tag N-His
Accession Number F8V4V0-1
Construction streptococcus pyogenes IdeS (F8V4V0-1) (Asp30-Asn341)
Protein Purity > 95 % as determined by SDS-PAGE.
Molecular Weight 36.2 kDa (predicted)
Endotoxin Please contact us for more information.
Formulation Supplied as sterile PBS, 50% Glycerol, pH 6. 6.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store the product under sterile conditions at -20℃ to -80℃. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.

Research Background IdeS (IgG-degrading enzyme of Streptococcus pyogenes) is a secreted cysteine endopeptidase from the human pathogen S. pyogenes with an extraordinarily high degree of substrate specificity, catalyzing a single proteolytic cleavage at the lower hinge of human IgG. This proteolytic degradation promotes inhibition of opsonophagocytosis and interferes with the killing of group A Streptococcus.

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Keywords

recombinant recombinant-proteins proteins protein

 

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