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RI(dl)-2 TFA

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Catalog No. T28536Cas No. 1902146-75-1
Alias RI(dl)-2

RI(dl)-2 TFA is a potent and selective inhibitor of RAD51-mediated D-loop formation, with an IC50 of 11.1 μM, and inhibits homologous recombination (HR) activity in human cells with an IC50 of 3.0 μM [1].

RI(dl)-2 TFA

RI(dl)-2 TFA

😃Good
Catalog No. T28536Alias RI(dl)-2Cas No. 1902146-75-1
RI(dl)-2 TFA is a potent and selective inhibitor of RAD51-mediated D-loop formation, with an IC50 of 11.1 μM, and inhibits homologous recombination (HR) activity in human cells with an IC50 of 3.0 μM [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,3504-6 weeks4-6 weeks
50 mg$1,7604-6 weeks4-6 weeks
100 mg$2,6804-6 weeks4-6 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
RI(dl)-2 TFA is a potent and selective inhibitor of RAD51-mediated D-loop formation, with an IC50 of 11.1 μM, and inhibits homologous recombination (HR) activity in human cells with an IC50 of 3.0 μM [1].
In vitro
RI(dl)-2 stabilizes nucleoprotein filaments in a nonfunctional state, rendering them incapable of D-loop activity and simultaneously shielding them from related pathways (e.g., RAD52-mediated SSA) [1]. Under high salt concentrations, RI(dl)-2 does not alter the affinity of RAD51 for ssDNA or the stability of preformed RAD51-ssDNA complexes [1].
SynonymsRI(dl)-2
Chemical Properties
Molecular Weight287.36
FormulaC19H17N3
Cas No.1902146-75-1
Relative Density.1.17 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

RI(dl)-2 TFARI(dl)2 TFARI(dl) 2 TFA
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