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Biotin-NH-PSMA-617

🥰Excellent
Catalog No. T78412

Biotin-NH-PSMA-617 is a biotinylated derivative of the small molecule PSMA-617, designed to target prostate-specific membrane antigen (PSMA), which is prominently expressed on prostate tumor cells. The biotinylation of PSMA-617 enhances its ability to bind PSMA, making it a valuable tool in the targeting of prostate cancer cells for diagnostic and therapeutic applications.

Biotin-NH-PSMA-617

Biotin-NH-PSMA-617

🥰Excellent
Catalog No. T78412
Biotin-NH-PSMA-617 is a biotinylated derivative of the small molecule PSMA-617, designed to target prostate-specific membrane antigen (PSMA), which is prominently expressed on prostate tumor cells. The biotinylation of PSMA-617 enhances its ability to bind PSMA, making it a valuable tool in the targeting of prostate cancer cells for diagnostic and therapeutic applications.
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1 mg$809In Stock
5 mg$1,660In Stock
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Product Introduction

Bioactivity
Description
Biotin-NH-PSMA-617 is a biotinylated derivative of the small molecule PSMA-617, designed to target prostate-specific membrane antigen (PSMA), which is prominently expressed on prostate tumor cells. The biotinylation of PSMA-617 enhances its ability to bind PSMA, making it a valuable tool in the targeting of prostate cancer cells for diagnostic and therapeutic applications.
In vitro
Biotin-NH-PSMA-617, a PSMA ligand, demonstrates significantly enhanced binding affinity to PSMA and efficient internalization into PCa cells. It can be labeled with 68Ga, 177Lu, 111In, and 90Y, allowing for its application in PET imaging and radioligand-based therapy [1].
Chemical Properties
Molecular Weight1396.62
FormulaC65H97N13O19S
SmilesC1CC(CCC1CNC(=O)[C@H](CCCCNC(=O)CCCC[C@H]2[C@@H]3[C@H](CS2)NC(=O)N3)NC(=O)CN4CCN(CCN(CCN(CC4)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@H](CC5=CC6=CC=CC=C6C=C5)C(=O)NCCCC[C@@H](C(=O)O)NC(=O)N[C@@H](CCC(=O)O)C(=O)O
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: ≥ 40 mg/mL, Sonication is recommended.

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