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Robatumumab (Synonyms: School 717454, Sch717454, Sch 717454, MK-7454, MK7454, 19D12)
Catalog No. T76759 Copy Product Info
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Robatumumab (Sch 717454) is a fully human anti-insulin-like growth factor receptor type 1 (IGF-1R) monoclonal antibody with antitumor and antiproliferative activity.Robatumumab is used in the study of ovarian cancer.
Robatumumab
Copy Product Info🥰Excellent
Catalog No. T76759
Synonyms School 717454, Sch717454, Sch 717454, MK-7454, MK7454, 19D12
Robatumumab (Sch 717454) is a fully human anti-insulin-like growth factor receptor type 1 (IGF-1R) monoclonal antibody with antitumor and antiproliferative activity.Robatumumab is used in the study of ovarian cancer.
Robatumumab
Cas No. 934235-44-6
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $189 | In Stock | In Stock | |
| 5 mg | $479 | In Stock | In Stock | |
| 10 mg | $768 | - | In Stock | |
| 25 mg | $1,150 | - | In Stock | |
| 50 mg | $1,550 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:96.9% (SDS-PAGE); 98.1% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Robatumumab (Sch 717454) is a fully human anti-insulin-like growth factor receptor type 1 (IGF-1R) monoclonal antibody with antitumor and antiproliferative activity.Robatumumab is used in the study of ovarian cancer. |
| In vitro | Robatumumab (0.02-80 nM; 0.5 or 4 hours) inhibited basal and IGF-I-induced phosphorylation of IGF-IR and IRS-1 in SK-N-FI cells by decreasing IGF-IR expression levels. [2] |
| In vivo | Robatumumab (i.v.; 0.04 or 0.1 mg/mouse; twice weekly; 18 days total) reduced SK-N-FI tumor growth in a xenograft model. [2] Robatumumab (i.v.; 0.02-0.5 mg/mouse; twice weekly; 35 days) was effective in inhibiting osteosarcoma expansion in a xenograft model. [2] Robatumumab (i.v.; 0.1 or 0.5 mg/mouse; twice weekly; 14 days) significantly inhibited the proliferation of SJCRH30 and RD rhabdomyosarcoma cells in a xenograft model. [2] Robatumumab (intravenous; 0.1 or 0.5 mg/mouse; twice weekly; 2 weeks) effectively blocked the growth of pediatric tumor cells in vivo. [2] Robatumumab (i.v.; 0.5 mg/mouse; single dose; day 11 post-vaccination) regulates blood vessel formation by exerting anti-angiogenic effects. [2] |
| Synonyms | School 717454, Sch717454, Sch 717454, MK-7454, MK7454, 19D12 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | IGF1-R/IGFR1/CD221 |
| Molecular Weight | 145.56 kDa |
| Cas No. | 934235-44-6 |
| Isotype | IgG1 |
| Storage | -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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