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Robatumumab (Synonyms: School 717454, Sch717454, Sch 717454, MK-7454, MK7454, 19D12)
Catalog No. T76759 Copy Product Info
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Robatumumab (Sch 717454) is a fully human anti-insulin-like growth factor receptor type 1 (IGF-1R) monoclonal antibody with antitumor and antiproliferative activity.Robatumumab is used in the study of ovarian cancer.
Robatumumab
Copy Product Info🥰Excellent
Catalog No. T76759
Synonyms School 717454, Sch717454, Sch 717454, MK-7454, MK7454, 19D12
Robatumumab (Sch 717454) is a fully human anti-insulin-like growth factor receptor type 1 (IGF-1R) monoclonal antibody with antitumor and antiproliferative activity.Robatumumab is used in the study of ovarian cancer.
Robatumumab
Cas No. 934235-44-6
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $189 | In Stock | In Stock | |
| 5 mg | $479 | In Stock | In Stock | |
| 10 mg | $768 | - | In Stock | |
| 25 mg | $1,150 | - | In Stock | |
| 50 mg | $1,550 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:96.9% (SDS-PAGE); 98.1% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Robatumumab (Sch 717454) is a fully human anti-insulin-like growth factor receptor type 1 (IGF-1R) monoclonal antibody with antitumor and antiproliferative activity.Robatumumab is used in the study of ovarian cancer. |
| In vitro | Robatumumab (0.02-80 nM; 0.5 or 4 hours) inhibited basal and IGF-I-induced phosphorylation of IGF-IR and IRS-1 in SK-N-FI cells by decreasing IGF-IR expression levels. [2] |
| In vivo | Robatumumab (i.v.; 0.04 or 0.1 mg/mouse; twice weekly; 18 days total) reduced SK-N-FI tumor growth in a xenograft model. [2] Robatumumab (i.v.; 0.02-0.5 mg/mouse; twice weekly; 35 days) was effective in inhibiting osteosarcoma expansion in a xenograft model. [2] Robatumumab (i.v.; 0.1 or 0.5 mg/mouse; twice weekly; 14 days) significantly inhibited the proliferation of SJCRH30 and RD rhabdomyosarcoma cells in a xenograft model. [2] Robatumumab (intravenous; 0.1 or 0.5 mg/mouse; twice weekly; 2 weeks) effectively blocked the growth of pediatric tumor cells in vivo. [2] Robatumumab (i.v.; 0.5 mg/mouse; single dose; day 11 post-vaccination) regulates blood vessel formation by exerting anti-angiogenic effects. [2] |
| Synonyms | School 717454, Sch717454, Sch 717454, MK-7454, MK7454, 19D12 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | IGF1-R/IGFR1/CD221 |
| Molecular Weight | 145.56 kDa |
| Cas No. | 934235-44-6 |
| Isotype | IgG1 |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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