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Robatumumab
🥰Excellent
Catalog No. T76759Cas No. 934235-44-6
Alias School 717454, Sch717454, Sch 717454, MK-7454, MK7454, 19D12
Robatumumab (Sch 717454) is a fully human anti-insulin-like growth factor receptor type 1 (IGF-1R) monoclonal antibody with antitumor and antiproliferative activity.Robatumumab is used in the study of ovarian cancer.
Robatumumab
Robatumumab
🥰Excellent
Catalog No. T76759Alias School 717454, Sch717454, Sch 717454, MK-7454, MK7454, 19D12Cas No. 934235-44-6
Robatumumab (Sch 717454) is a fully human anti-insulin-like growth factor receptor type 1 (IGF-1R) monoclonal antibody with antitumor and antiproliferative activity.Robatumumab is used in the study of ovarian cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $189 | In Stock | In Stock | |
| 5 mg | $479 | In Stock | In Stock | |
| 10 mg | $768 | - | In Stock | |
| 25 mg | $1,150 | - | In Stock | |
| 50 mg | $1,550 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:96.9% (SDS-PAGE); 98.1% (SEC-HPLC)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Robatumumab (Sch 717454) is a fully human anti-insulin-like growth factor receptor type 1 (IGF-1R) monoclonal antibody with antitumor and antiproliferative activity.Robatumumab is used in the study of ovarian cancer. |
| In vitro | Robatumumab (0.02-80 nM; 0.5 or 4 hours) inhibited basal and IGF-I-induced phosphorylation of IGF-IR and IRS-1 in SK-N-FI cells by decreasing IGF-IR expression levels. [2] |
| In vivo | Robatumumab (i.v.; 0.04 or 0.1 mg/mouse; twice weekly; 18 days total) reduced SK-N-FI tumor growth in a xenograft model. [2] Robatumumab (i.v.; 0.02-0.5 mg/mouse; twice weekly; 35 days) was effective in inhibiting osteosarcoma expansion in a xenograft model. [2] Robatumumab (i.v.; 0.1 or 0.5 mg/mouse; twice weekly; 14 days) significantly inhibited the proliferation of SJCRH30 and RD rhabdomyosarcoma cells in a xenograft model. [2] Robatumumab (intravenous; 0.1 or 0.5 mg/mouse; twice weekly; 2 weeks) effectively blocked the growth of pediatric tumor cells in vivo. [2] Robatumumab (i.v.; 0.5 mg/mouse; single dose; day 11 post-vaccination) regulates blood vessel formation by exerting anti-angiogenic effects. [2] |
| Synonyms | School 717454, Sch717454, Sch 717454, MK-7454, MK7454, 19D12 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Host Species | ＜ 1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID |
| Cas No. | 934235-44-6 |
| Color | Transparent |
| Appearance | Liquid |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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