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Lenalidomide-C5-NH2

Name: Lenalidomide-C5-NH2
Brand: TargetMol
SKU: T17928
Rating: 4.5 (1 reviews)

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Catalog No. T17928Cas No. 2093388-45-3

Alias E3 ligase Ligand-Linker Conjugates 31, Cereblon Ligand-Linker Conjugates 19

Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs[1].

Lenalidomide-C5-NH2

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Catalog No. T17928Alias E3 ligase Ligand-Linker Conjugates 31, Cereblon Ligand-Linker Conjugates 19Cas No. 2093388-45-3

Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs[1].

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	Inquiry	Inquiry	Inquiry
500 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs[1].
Synonyms	E3 ligase Ligand-Linker Conjugates 31, Cereblon Ligand-Linker Conjugates 19

Chemical Properties

Molecular Weight	329.39
Formula	C₁₈H₂₃N₃O₃
Cas No.	2093388-45-3
Smiles	O=C1NC(=O)C(N2C(=O)C3=CC=CC(=C3C2)CCCCCN)CC1
Relative Density.	1.260 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5 mg/mL (15.18 mM), Sonication is recommended.

H2O: 50 mg/mL (151.8 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.0359 mL	15.1796 mL	30.3591 mL	151.7957 mL
5 mM	0.6072 mL	3.0359 mL	6.0718 mL	30.3591 mL
10 mM	0.3036 mL	1.5180 mL	3.0359 mL	15.1796 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.1518 mL	0.7590 mL	1.5180 mL	7.5898 mL
50 mM	0.0607 mL	0.3036 mL	0.6072 mL	3.0359 mL
100 mM	0.0304 mL	0.1518 mL	0.3036 mL	1.5180 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc