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M47
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Catalog No. T74743Cas No. 890808-56-7
Alias M-47
M47 is a selective CRY1 (Cryptochrome 1) degradator that enhances nuclear degradation of CRY1 and disrupts its stability, thereby extending the lifespan of p53 knockout mice. It facilitates research into various cancers involving p53 mutations.
M47
😃Good
Catalog No. T74743Alias M-47Cas No. 890808-56-7
M47 is a selective CRY1 (Cryptochrome 1) degradator that enhances nuclear degradation of CRY1 and disrupts its stability, thereby extending the lifespan of p53 knockout mice. It facilitates research into various cancers involving p53 mutations.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | - | In Stock | |
| 5 mg | Inquiry | - | In Stock | |
| 10 mg | Inquiry | 7-10 days | 7-10 days | |
| 25 mg | Inquiry | 7-10 days | 7-10 days | |
| 50 mg | Inquiry | 7-10 days | 7-10 days | |
| 100 mg | Inquiry | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | M47 is a selective CRY1 (Cryptochrome 1) degradator that enhances nuclear degradation of CRY1 and disrupts its stability, thereby extending the lifespan of p53 knockout mice. It facilitates research into various cancers involving p53 mutations. |
| In vitro | In U2OS Bmal1-dLuc cells, M47 (0-10 μM, 0-120 hours) can shorten the half-life of CRY1 (Cryptochrome 1) in a dose-dependent manner and induce circadian rhythm alterations [1]. In U2OS cells, M47 (10 μM, 24-44 hours) can reduce the protein level of CRY1 in the cells [1]. |
| In vivo | In C57BL/6J mice and p53 gene knockout C57BL/6J mice, M47 (5-1000 mg/kg, intraperitoneal injection, once daily for 5 consecutive days) selectively shortened the half-life of CRY1 (cryptochrome 1); M47 exhibited good tolerability in vivo, possessed excellent pharmacokinetic characteristics, and also promoted apoptosis [1]. |
| Synonyms | M-47 |
| Molecular Weight | 471.93 |
| Formula | C28H22ClNO4 |
| Cas No. | 890808-56-7 |
| Smiles | O=C(C=1OC2=CC=C3OC(C4=CC=C(Cl)C=C4)(C)CC(=O)C3=C2C1C)N5C=6C=CC=CC6CC5 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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