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M47
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Catalog No. T74743Cas No. 890808-56-7
Alias M-47
M47 is a selective CRY1 (Cryptochrome 1) degradator that enhances nuclear degradation of CRY1 and disrupts its stability, thereby extending the lifespan of p53 knockout mice. It facilitates research into various cancers involving p53 mutations.
M47
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Purity: 98.31%
Catalog No. T74743Alias M-47Cas No. 890808-56-7
M47 is a selective CRY1 (Cryptochrome 1) degradator that enhances nuclear degradation of CRY1 and disrupts its stability, thereby extending the lifespan of p53 knockout mice. It facilitates research into various cancers involving p53 mutations.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $117 | - | In Stock | |
| 5 mg | $289 | - | In Stock | |
| 10 mg | $463 | - | In Stock | |
| 25 mg | $839 | - | In Stock | |
| 50 mg | $1,130 | - | In Stock | |
| 100 mg | $1,520 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.31%
Appearance:Solid
Color:White to Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | M47 is a selective CRY1 (Cryptochrome 1) degradator that enhances nuclear degradation of CRY1 and disrupts its stability, thereby extending the lifespan of p53 knockout mice. It facilitates research into various cancers involving p53 mutations. |
| In vitro | In U2OS Bmal1-dLuc cells, M47 (0-10 μM, 0-120 hours) can shorten the half-life of CRY1 (Cryptochrome 1) in a dose-dependent manner and induce circadian rhythm alterations [1]. In U2OS cells, M47 (10 μM, 24-44 hours) can reduce the protein level of CRY1 in the cells [1]. |
| In vivo | In C57BL/6J mice and p53 gene knockout C57BL/6J mice, M47 (5-1000 mg/kg, intraperitoneal injection, once daily for 5 consecutive days) selectively shortened the half-life of CRY1 (cryptochrome 1); M47 exhibited good tolerability in vivo, possessed excellent pharmacokinetic characteristics, and also promoted apoptosis [1]. |
| Synonyms | M-47 |
| Molecular Weight | 471.93 |
| Formula | C28H22ClNO4 |
| Cas No. | 890808-56-7 |
| Smiles | O=C(C=1OC2=CC=C3OC(C4=CC=C(Cl)C=C4)(C)CC(=O)C3=C2C1C)N5C=6C=CC=CC6CC5 |
| Storage | keep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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