keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TRV055 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 is efficacious in stimulating cellular Gq-mediated signaling. TRV055 can be used to develop the Gq-biased AT1R agonists.
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Description | TRV055 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 is efficacious in stimulating cellular Gq-mediated signaling. TRV055 can be used to develop the Gq-biased AT1R agonists. |
In vitro | TRV055 is a “gain-of-function” ligand that have >10-fold greater allosteric coupling to Gq than AngII and is also more efficacious in stimulating cellular Gq-mediated signaling (e.g., IP1 generation). Compared to the endogenous ligand angiotensin II (AngII), “Gq-biased” AT1R agonists are more efficacious in stimulating Gq-mediated cellular signaling and in allosterically promoting Gq coupling[1]. |
Synonyms | TRV055 |
Molecular Weight | 831.972 |
Formula | C42H57N9O9 |
CAS No. | 25849-90-5 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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TRV055 25849-90-5 TRV-055 TRV 055 inhibitor inhibit