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Damnacanthal (Alias: Damnacantal)

Name: Damnacanthal
Brand: TargetMol
SKU: TN1549
Rating: 4.5 (1 reviews)

Catalog No. TN1549 Copy Product Info

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Damnacanthal is a natural anthraquinone compound with potential anticancer, anti-inflammatory, antioxidant, anti-malarial, and antiviral effects.Damnacanthal inhibits a variety of protein kinases such as LIMK1 (IC50=0.8 μM), LIMK2 (IC50=1.5 μM), and Lck (IC50=17 nM), and inhibits the growth of human hepatocellular carcinoma (SKHep-1) and human breast cancer (MCF-7) cells.

Damnacanthal

Copy Product Info

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Catalog No. TN1549

Alias Damnacantal

Cas No. 477-84-9

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$800	Inquiry	Inquiry

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Damnacanthal is a natural anthraquinone compound with potential anticancer, anti-inflammatory, antioxidant, anti-malarial, and antiviral effects.Damnacanthal inhibits a variety of protein kinases such as LIMK1 (IC50=0.8 μM), LIMK2 (IC50=1.5 μM), and Lck (IC50=17 nM), and inhibits the growth of human hepatocellular carcinoma (SKHep-1) and human breast cancer (MCF-7) cells.
Targets&IC50	p56lck autophosphorylation:46 nM (IC50), Phosphorylation of exogenous substrates by p56lck:220 nM (IC50)
In vitro	Methods: Damnacanthal (100nM, 1, 10, 100μM, 1, 2, 4 days) was used to treat HCT-116 and SW480 cells to study its antiproliferative effects on human colorectal cancer cell types. Results: Treatment of HCT-116 cells with Damnacanthal resulted in a significant decrease in cell proliferation at 1 μM (P < 0.05), 10 μM (P < 0.01), and 100 μM (P < 0.01) after 4 days of treatment; SW480 cells also showed a significant decrease in cell proliferation at 10 μM (P < 0.05) and 100 μM (P < 0.001) after 4 days of treatment with Damnacanthal; Damnacanthal had a cytotoxic effect on colorectal cancer cells in both p53 wild-type (HCT-116) and p53 mutant (SW480) cells. Methods: HCT-116 cells were treated with Damnacanthal (1, 10, 50 μM) to determine its possible inhibitory effects on cell cycle progression and apoptosis, and caspase 3/7 activity was measured. Results: Treatment of HCT-116 cells with Damnacanthal (50 μM) resulted in a significant enrichment of cells in the S/G1 and G2/G1 phases. Treatment of HCT-116 cells with Damnacanthal (10 μM) significantly increased caspase 3/7 activity. [2]
In vivo	Damnacanthal (10-100 mg/kg, oral, 10-300 minutes) treatment of mice showed a dose-dependent and significant antinociceptive effect in the formalin test, and mice treated with Damnacanthal (100 mg/kg) significantly inhibited histamine-induced paw edema[3].
Synonyms	Damnacantal

Chemical Properties

Molecular Weight	282.25
Formula	C₁₆H₁₀O₅
Cas No.	477-84-9
Smiles	O=CC1=C(O)C=C2C(=O)C=3C=CC=CC3C(=O)C2=C1OC
Relative Density.	1.461g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 2 mg/mL (7.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5430 mL	17.7148 mL	35.4296 mL	177.1479 mL
5 mM	0.7086 mL	3.5430 mL	7.0859 mL	35.4296 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc