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S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine

Catalog No. T83898 CAS 364083-21-6

Synonyms: SFN-Cys, D,L-Sulforaphane-L-cysteine

S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine (SFN-Cys) is an isothiocyanate derivative, functioning as an active metabolite of sulforaphane, a class I and II histone deacetylase (HDAC) inhibitor, and anticancer agent. This compound is generated from sulforaphane through intermediates - DL-sulforaphane glutathione and sulforaphane cysteinylglycine - via the mercapturic acid pathway enzymes. At a concentration of 20 µM, SFN-Cys diminishes invasion and migration of U87MG and U373 MG glioblastoma cells as observed in wound healing and chamber assays. Furthermore, at 45 µM, it significantly lowers the expression of α-tubulin, βIII-tubulin, stathmin 1, and X-linked inhibitor of apoptosis (XIAP), and also reduces cell density in paclitaxel-resistant A549 lung cancer cells (A549/T). Additionally, when used at 30 µM, SFN-Cys prompts apoptosis and cell cycle arrest at the G2/M phase in U87MG and U373 MG cells.

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S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine Chemical Structure

S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine, CAS 364083-21-6

Pack Size	Availability	Price/USD	Quantity
5 mg	35 days	$ 550.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	SFN-Cys, D,L-Sulforaphane-L-cysteine
Molecular Weight	298.45
Formula	C9H18N2O3S3
CAS No.	364083-21-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Methanol: slightly soluble

Ethanol: slightly soluble

H2O: slightly soluble

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine 364083-21-6 SFN-Cys D,L-Sulforaphane-L-cysteine inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.