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Pyrogallol-phloroglucinol-6,6-bieckol

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Catalog No. TN7775Cas No. 1415504-32-3

Pyrogallol-phloroglucinol-6,6-bieckol (PPB) is a bioactive phlorotannin compound isolated from the brown alga Ecklonia cava that exerts potent anti-inflammatory and anti-atherogenic activities by inhibiting monocyte migration and macrophage differentiation toward inflammatory phenotypes. Pyrogallol-phloroglucinol-6,6-bieckol reduces monocyte-induced endothelial cell death and suppresses vascular smooth muscle cell proliferation and migration, contributing to vascular protection and potential therapeutic modulation of inflammatory vascular diseases.

Pyrogallol-phloroglucinol-6,6-bieckol

Pyrogallol-phloroglucinol-6,6-bieckol

😃Good
Catalog No. TN7775Cas No. 1415504-32-3
Pyrogallol-phloroglucinol-6,6-bieckol (PPB) is a bioactive phlorotannin compound isolated from the brown alga Ecklonia cava that exerts potent anti-inflammatory and anti-atherogenic activities by inhibiting monocyte migration and macrophage differentiation toward inflammatory phenotypes. Pyrogallol-phloroglucinol-6,6-bieckol reduces monocyte-induced endothelial cell death and suppresses vascular smooth muscle cell proliferation and migration, contributing to vascular protection and potential therapeutic modulation of inflammatory vascular diseases.
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Pyrogallol-phloroglucinol-6,6-bieckol (PPB) is a bioactive phlorotannin compound isolated from the brown alga Ecklonia cava that exerts potent anti-inflammatory and anti-atherogenic activities by inhibiting monocyte migration and macrophage differentiation toward inflammatory phenotypes. Pyrogallol-phloroglucinol-6,6-bieckol reduces monocyte-induced endothelial cell death and suppresses vascular smooth muscle cell proliferation and migration, contributing to vascular protection and potential therapeutic modulation of inflammatory vascular diseases.
Chemical Properties
Molecular Weight974.74
FormulaC48H30O23
Cas No.1415504-32-3
SmilesOC=1C=C(O)C=C(OC2=C(O)C=C(OC3=CC(O)=CC(OC4=C(O)C=C(O)C=5OC=6C(OC45)=C(O)C=C(O)C6C7=C(O)C=C(O)C=8OC=9C(OC=%10C=C(O)C=C(O)C%10)=C(O)C=C(O)C9OC87)=C3)C=C2O)C1
ColorBrown
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (82.07 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.0259 mL5.1296 mL10.2591 mL51.2957 mL
5 mM0.2052 mL1.0259 mL2.0518 mL10.2591 mL
10 mM0.1026 mL0.5130 mL1.0259 mL5.1296 mL
20 mM0.0513 mL0.2565 mL0.5130 mL2.5648 mL
50 mM0.0205 mL0.1026 mL0.2052 mL1.0259 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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