MGMT Protein, Human, Recombinant (His)

Name: MGMT Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPJ-00872
Rating: 4.5 (1 reviews)

(Synonyms: O-6-methylguanine-DNA-alkyltransferase, MGMT, Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNAmethyltransferase) Copy Product Info

Synonyms: O-6-methylguanine-DNA-alkyltransferase, MGMT, Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNAmethyltransferase

Catalog No. TMPJ-00872 Copy Product Info

MGMT belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. MGMT involved in the cellular defense against the biological effects of O6-methylguanine in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. MGMT catalyzes the chemical reaction: DNA (containing 6-O-methylguanine) and proteinL-cysteine into DNA (without 6-O-methylguanine) and protein S-methyl-L-cysteine.

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Pack Size	Price	USA Stock	Global Stock
10 µg	$116	7-10 days	7-10 days
20 µg	$186	7-10 days	7-10 days
50 µg	$352	7-10 days	7-10 days
100 µg	$582	7-10 days	7-10 days
200 µg	$967	7-10 days	7-10 days
500 µg	$1,900	7-10 days	7-10 days
1 mg	$2,730	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	MGMT belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. MGMT involved in the cellular defense against the biological effects of O6-methylguanine in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. MGMT catalyzes the chemical reaction: DNA (containing 6-O-methylguanine) and proteinL-cysteine into DNA (without 6-O-methylguanine) and protein S-methyl-L-cysteine.
Species	Human
Expression System	E. coli
Tag	N-6xHis
Accession Number	P16455
Amino Acid	Met1-Asn207
Construction	Met1-Asn207
Protein Purity	Greater than 90% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 1 mM DTT, 1 mM EDTA, 500 mM NaCl, 0.1%Trition X-100, pH 8.0.
Synonyms	O-6-methylguanine-DNA-alkyltransferase, MGMT, Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNAmethyltransferase
Research Background	MGMT belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. MGMT involved in the cellular defense against the biological effects of O6-methylguanine in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. MGMT catalyzes the chemical reaction: DNA (containing 6-O-methylguanine) and proteinL-cysteine into DNA (without 6-O-methylguanine) and protein S-methyl-L-cysteine.

Chemical Properties

Molecular Weight

25 KDa (reducing condition)

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.