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SY-LB-57
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Catalog No. T60429Cas No. 2253719-35-4
SY-LB-57 is a highly effective agonist of bone morphogenetic protein (BMP) receptor signaling, suitable for studies of conditions such as bone fractures and pulmonary arterial hypertension [1].
SY-LB-57
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Catalog No. T60429Cas No. 2253719-35-4
SY-LB-57 is a highly effective agonist of bone morphogenetic protein (BMP) receptor signaling, suitable for studies of conditions such as bone fractures and pulmonary arterial hypertension [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $83 | 5 days | 5 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SY-LB-57 is a highly effective agonist of bone morphogenetic protein (BMP) receptor signaling, suitable for studies of conditions such as bone fractures and pulmonary arterial hypertension [1]. |
| In vitro | SY-LB-57 (0.01-1000 μM, 24 h) induces cell proliferation at concentrations below 10 μM, with an IC50 value of 807.93 μM in C2C12 cells [1]. It increases Smad protein phosphorylation, promotes p-Smad nuclear translocation, activates the PI3K/Akt pathway, and induces cytoplasmic localization of p-Akt at 0.01-10 μM for 15-30 min [1]. Additionally, SY-LB-57 (0.01-10 μM, 24 h) shifts the cell cycle towards the S and G2/M phases [1]. Cell Viability Assay [1]: SY-LB-57 (0.01-1000 μM) increased cell viability in C2C12 cells by 280-50% at concentrations from 0.01 μM to 100 μM compared to control. Western Blot Analysis [1]: SY-LB-57 (0.01-10 μM) significantly increased Smad phosphorylation by 50-257% after 30 min and p-Akt expression by 667-1081% after 15 min. Cell Cycle Analysis [1]: SY-LB-57 (0.01-10 μM) shifted the cell cycle towards proliferation with a decrease in G0/G1 phase cells and an increase in S and G2/M phase cells. |
| Molecular Weight | 263.29 |
| Formula | C16H13N3O |
| Cas No. | 2253719-35-4 |
| Smiles | O(C)C=1C=C2C=C(NC2=CC1)C=3NC=4C(N3)=CC=CC4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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