Powder: -20°C for 3 years | In solvent: -80°C for 1 year
22-(4′-py)-JA, a semisynthetic derivative of junamycin A isolated from the Thai blue sponge (Xestospongia sp.), exhibits antimetastatic properties by inhibiting the AKT/mTOR/p70S6K signaling pathway. It also impedes tumor cell invasion and angiogenesis in human umbilical vein endothelial cells (HUVEC), while suppressing the expression of metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1α (HIF-1α), and vascular endothelial growth factor (VEGF). Its potent anticancer activity is particularly noted against non-small cell lung cancer (NSCLC) [1].
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Description | 22-(4′-py)-JA, a semisynthetic derivative of junamycin A isolated from the Thai blue sponge (Xestospongia sp.), exhibits antimetastatic properties by inhibiting the AKT/mTOR/p70S6K signaling pathway. It also impedes tumor cell invasion and angiogenesis in human umbilical vein endothelial cells (HUVEC), while suppressing the expression of metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1α (HIF-1α), and vascular endothelial growth factor (VEGF). Its potent anticancer activity is particularly noted against non-small cell lung cancer (NSCLC) [1]. |
Synonyms | 22-(4′-Pyridinecarbonyl) jorunnamycin A |
Molecular Weight | 598.6 |
Formula | C32H30N4O8 |
CAS No. | 1178895-15-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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22-(4′-py)-JA 1178895-15-2 Cytoskeletal Signaling PI3K/Akt/mTOR signaling Akt 22-(4′-Pyridinecarbonyl) jorunnamycin A inhibitor inhibit