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L-Sepiapterin
(Synonyms: Sepiapterin) Copy Product Info
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Synonyms: Sepiapterin
Catalog No. T38250 Copy Product Info
Purity: 99.97%
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L-Sepiapterin is an activator of phenylalanine hydroxylase and also a synthetic precursor of tetrahydrobiopterin, a cofactor of endothelial nitric oxide synthase. L-Sepiapterin can improve endothelial dysfunction in mesenteric arterioles of db/db mice and induce angiogenesis; meanwhile, L-Sepiapterin can also inhibit the proliferation and migration of ovarian cancer cells by downregulating p70S6K-dependent VEGFR-2 expression. Based on the above biological activities, L-Sepiapterin can be applied to mechanistic studies related to hyperphenylalaninemia.
Cas No. 17094-01-8
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $1,050 | - | In Stock | |
| 5 mg | $2,090 | - | In Stock | |
| 10 mg | $2,830 | - | In Stock | |
| 25 mg | $4,230 | - | In Stock | |
| 50 mg | $5,500 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.97%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | L-Sepiapterin is an activator of phenylalanine hydroxylase and also a synthetic precursor of tetrahydrobiopterin, a cofactor of endothelial nitric oxide synthase. L-Sepiapterin can improve endothelial dysfunction in mesenteric arterioles of db/db mice and induce angiogenesis; meanwhile, L-Sepiapterin can also inhibit the proliferation and migration of ovarian cancer cells by downregulating p70S6K-dependent VEGFR-2 expression. Based on the above biological activities, L-Sepiapterin can be applied to mechanistic studies related to hyperphenylalaninemia. |
| In vitro | Methods: Cells were treated with L-Sepiapterin (0.1–10 μM) for 24 hours. Results: L-Sepiapterin induced cell proliferation in a dose‑dependent manner. Methods: Cells were first induced with VEGF‑A (50 ng/mL), then treated with L-Sepiapterin (1–50 μM) for 20 minutes. Results: L-Sepiapterin significantly inhibited VEGF‑A‑induced p70S6K phosphorylation. Methods: Relevant intervention experiments were performed using cell proliferation assays. Results: L-Sepiapterin inhibited VEGF‑A‑induced protein phosphorylation, cell proliferation and migration through an NO‑independent mechanism[1]. |
| In vivo | Methods: db/db mice were intragastrically administered L-Sepiapterin (10 mg/kg; via powdered food) once daily for 8 consecutive weeks. Results: L-Sepiapterin significantly improved the relaxation response of superior mesenteric arteries (SMA) to acetylcholine (Ach) in db/db mice[2]. |
| Synonyms | Sepiapterin |
| Molecular Weight | 237.22 |
| Formula | C9H11N5O3 |
| Cas No. | 17094-01-8 |
| Smiles | O=C1C2=C(NCC(C([C@H](C)O)=O)=N2)NC(N)=N1 |
| Storage | Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Related Tags: L-Sepiapterin chemical structure | L-Sepiapterin in vivo | L-Sepiapterin in vitro | L-Sepiapterin formula | L-Sepiapterin molecular weight
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