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M2698

Name: M2698
Brand: TargetMol
SKU: T11928
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11928Cas No. 1379545-95-5

Alias MSC2363318A

M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity.

M2698

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Purity: 99.88%

Catalog No. T11928Alias MSC2363318ACas No. 1379545-95-5

M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity.

Pack Size	Price	Availability
1 mg	$43	In Stock
5 mg	$107	In Stock
10 mg	$173	In Stock
25 mg	$347	In Stock
50 mg	$500	In Stock
100 mg	$690	In Stock
200 mg	$929	In Stock
1 mL x 10 mM (in DMSO)	$125	In Stock

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Purity:99.88%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity.
Targets&IC50	p70 S6K:1 nM, Akt1:1 nM, Akt3:1 nM
In vitro	M2698 (0.3 nM-50 M) dose-dependently inhibits proliferation in breast tumor cell lines (IC50s: 0.02-8.5 µM). M2698 (0.3-1 µM) induces feedback loop phosphorylation on Akt and suppresses Akt and p70S6K activity in HCC1419 and MDA-MB-453 cells. M2698 inhibits indirectly pGSK3β and pS6 with IC50s of 17 and 15 nM[1].
In vivo	Gavage administration of M2698 (10-30 mg/kg) dose-dependently inhibits the growth of tumors and increases pAkt levels in tumor tissue. M2698 (30 mg/kg) causes tumor regression. M2698 (1-20 mg/kg) inhibits S6 phosphorylation in a dose-proportional manner over time[1].
Synonyms	MSC2363318A

Chemical Properties

Molecular Weight	449.86
Formula	C₂₁H₁₉ClF₃N₅O
Cas No.	1379545-95-5
Smiles	N([C@H](CN1CCC1)C2=CC(C(F)(F)F)=C(Cl)C=C2)C=3C4=C(C(C(N)=O)=CC=C4)N=CN3
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 112.5 mg/mL (250.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2229 mL	11.1146 mL	22.2291 mL	111.1457 mL
5 mM	0.4446 mL	2.2229 mL	4.4458 mL	22.2291 mL
10 mM	0.2223 mL	1.1115 mL	2.2229 mL	11.1146 mL
20 mM	0.1111 mL	0.5557 mL	1.1115 mL	5.5573 mL
50 mM	0.0445 mL	0.2223 mL	0.4446 mL	2.2229 mL
100 mM	0.0222 mL	0.1111 mL	0.2223 mL	1.1115 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc