Shopping Cart
Remove All
Your shopping cart is currently empty
Doxepin
Copy Product Info
😃Good
Catalog No. T60521Cas No. 1668-19-5
As a tricyclic antidepressant, Doxepin inhibits the reuptake of serotonin and norepinephrine. Doxepin shows therapeutic effects on atopic dermatitis and chronic urticaria that also improves cognitive processes as well as protect the central nervous system. Doxepin has anti-inflammatory effects and reduces oxidative stress[1] [2] [3].
Doxepin
Copy Product Info😃Good
Catalog No. T60521Cas No. 1668-19-5
As a tricyclic antidepressant, Doxepin inhibits the reuptake of serotonin and norepinephrine. Doxepin shows therapeutic effects on atopic dermatitis and chronic urticaria that also improves cognitive processes as well as protect the central nervous system. Doxepin has anti-inflammatory effects and reduces oxidative stress[1] [2] [3].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 1-2 weeks | 1-2 weeks | |
| 50 mg | $1,980 | 1-2 weeks | 1-2 weeks | |
| 100 mg | $2,500 | 1-2 weeks | 1-2 weeks |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Resource Download
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | As a tricyclic antidepressant, Doxepin inhibits the reuptake of serotonin and norepinephrine. Doxepin shows therapeutic effects on atopic dermatitis and chronic urticaria that also improves cognitive processes as well as protect the central nervous system. Doxepin has anti-inflammatory effects and reduces oxidative stress[1] [2] [3]. |
| In vitro | Doxepin enhances the expression of PSD-95 and synapsin 1 in SH-SY5Y human neuroblastoma cells through the PI3K/AKT/mTOR signaling pathway, as demonstrated in a Western Blot Analysis [4]. When treated with a concentration of 10 ng/mL for an incubation period of 2 hours, there was a noticeable increase in the protein expression levels of PSD-95, synapsin 1, and p-AKT, along with a decrease in p-mTOR expression in SH-SY5Y cells [4]. |
| In vivo | Doxepin, administered via intraperitoneal injection at doses of 1 mg/kg and 5 mg/kg once daily for 21 days, demonstrated protective effects against Aβ1-42-induced memory impairment in male SD rats. The treatment notably enhanced the expression of PSD-95 and synapsin 1 proteins in the hippocampus and temporal lobe, while reducing p-AKT protein levels in these areas following the 1 mg/kg dosage. |
| Molecular Weight | 279.38 |
| Formula | C19H21NO |
| Cas No. | 1668-19-5 |
| Smiles | C(CCN(C)C)=C1C=2C(COC=3C1=CC=CC3)=CC=CC2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Doxepin | purchase Doxepin | Doxepin cost | order Doxepin | Doxepin chemical structure | Doxepin in vivo | Doxepin in vitro | Doxepin formula | Doxepin molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.