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Doxepin

Catalog No. T60521 CAS 1668-19-5

As a tricyclic antidepressant, Doxepin inhibits the reuptake of serotonin and norepinephrine. Doxepin shows therapeutic effects on atopic dermatitis and chronic urticaria that also improves cognitive processes as well as protect the central nervous system. Doxepin has anti-inflammatory effects and reduces oxidative stress[1] [2] [3].

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Doxepin, CAS 1668-19-5

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 1,520.00
50 mg	8-10 weeks	$ 1,980.00
100 mg	8-10 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	As a tricyclic antidepressant, Doxepin inhibits the reuptake of serotonin and norepinephrine. Doxepin shows therapeutic effects on atopic dermatitis and chronic urticaria that also improves cognitive processes as well as protect the central nervous system. Doxepin has anti-inflammatory effects and reduces oxidative stress[1] [2] [3].
In vitro	Doxepin enhances the expression of PSD-95 and synapsin 1 in SH-SY5Y human neuroblastoma cells through the PI3K/AKT/mTOR signaling pathway, as demonstrated in a Western Blot Analysis [4]. When treated with a concentration of 10 ng/mL for an incubation period of 2 hours, there was a noticeable increase in the protein expression levels of PSD-95, synapsin 1, and p-AKT, along with a decrease in p-mTOR expression in SH-SY5Y cells [4].
In vivo	Doxepin, administered via intraperitoneal injection at doses of 1 mg/kg and 5 mg/kg once daily for 21 days, demonstrated protective effects against Aβ1-42-induced memory impairment in male SD rats. The treatment notably enhanced the expression of PSD-95 and synapsin 1 proteins in the hippocampus and temporal lobe, while reducing p-AKT protein levels in these areas following the 1 mg/kg dosage.

Molecular Weight	279.38
Formula	C19H21NO
CAS No.	1668-19-5

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Doxepin 1668-19-5 inhibitor inhibit

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