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Letaxaban

Name: Letaxaban
Brand: TargetMol
SKU: T68092
Price: 147 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T68092Cas No. 870262-90-1

Alias TAK-442

Letaxaban (TAK-442) is a small molecule Xa factor inhibitor that can be used to study polar coronary syndromes and thrombotic blockages.

Letaxaban

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Purity: 99.87%

Catalog No. T68092Alias TAK-442Cas No. 870262-90-1

Letaxaban (TAK-442) is a small molecule Xa factor inhibitor that can be used to study polar coronary syndromes and thrombotic blockages.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$147	In Stock	In Stock
5 mg	$378	In Stock	In Stock
10 mg	$545	In Stock	In Stock
25 mg	$826	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.87%

ee:100%

Appearance:Solid

Color:White

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COA LCMS CSFC HNMR

Product Introduction

Letaxaban AI Summary

Letaxaban exhibits metabolic stability in both human and monkey liver microsomes, showing no acid production after 2 hours. It demonstrates potent anticoagulant activity in human plasma, with an effective concentration of 0.58 µM to double prothrombin time, and significant inhibition of human factor 10a with an IC50 value of 3.5 nM and Ki of 1.8 nM. Selectivity ratios indicate a preference for factor 10a over other bioactivities tested. In a rabbit venous thrombosis model, Letaxaban shows dose-dependent inhibition of venous thrombus formation when administered intravenously. Additionally, it has a promising oral bioavailability of 52.5% in monkeys, with clearance and volume of distribution at steady state measured at 11.8 mL.min-1.kg-1 and 0.579 L.kg-1, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Letaxaban (TAK-442) is a small molecule Xa factor inhibitor that can be used to study polar coronary syndromes and thrombotic blockages.
Synonyms	TAK-442

Chemical Properties

Molecular Weight	479.98
Formula	C₂₂H₂₆ClN₃O₅S
Cas No.	870262-90-1
Smiles	ClC1=CC2=C(C=C(S(C[C@H](C(=O)N3CCC(CC3)N4C(=O)NCCC4)O)(=O)=O)C=C2)C=C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (104.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0834 mL	10.4171 mL	20.8342 mL	104.1710 mL
5 mM	0.4167 mL	2.0834 mL	4.1668 mL	20.8342 mL
10 mM	0.2083 mL	1.0417 mL	2.0834 mL	10.4171 mL
20 mM	0.1042 mL	0.5209 mL	1.0417 mL	5.2086 mL
50 mM	0.0417 mL	0.2083 mL	0.4167 mL	2.0834 mL
100 mM	0.0208 mL	0.1042 mL	0.2083 mL	1.0417 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc