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PCK2 Protein, Human, Recombinant (His & GST)

Catalog No. TMPY-04764
Synonyms: PEPCK-M, PEPCK2, PEPCK, phosphoenolpyruvate carboxykinase 2 (mitochondrial)

PCK2 promotes tumor initiation by lowering acetyl-CoA level through reducing the mitochondrial tricarboxylic acid (TCA) cycle. The levels of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) are critical for the metabolic switch and the maintenance of TICs in prostate cancer. PCK2 is a potential therapeutic target for aggressive prostate tumors.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
PCK2 Protein, Human, Recombinant (His & GST)
Pack Size Availability Price/USD Quantity
50 μg 5 days $ 600.00
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Biological Description
Technical Params
Product Properties
Description PCK2 promotes tumor initiation by lowering acetyl-CoA level through reducing the mitochondrial tricarboxylic acid (TCA) cycle. The levels of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) are critical for the metabolic switch and the maintenance of TICs in prostate cancer. PCK2 is a potential therapeutic target for aggressive prostate tumors.
Species Human
Expression System Baculovirus-Insect Cells
Tag His,GST
Accession Number A0A384MTT2
Synonyms PEPCK-M, PEPCK2, PEPCK, phosphoenolpyruvate carboxykinase 2 (mitochondrial)
Construction A DNA sequence encoding the human PCK2 (NP_004554.3) (Leu33-Met640) was expressed with a C-terminal polyhistidine-tagged GST tag at the N-terminus (his-GST).
Protein Purity > 90 % as determined by SDS-PAGE.
Molecular Weight 94.9 kDa (predicted)
Endotoxin < 1.0 EU per μg protein as determined by the LAL method.
Formulation Supplied as sterile 20 mM Tris, 500 mM NaCl, 10 %glycerol, pH 8.0. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Stability & Storage

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping

Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.

Research Background PCK2 promotes tumor initiation by lowering acetyl-CoA level through reducing the mitochondrial tricarboxylic acid (TCA) cycle. The levels of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) are critical for the metabolic switch and the maintenance of TICs in prostate cancer. PCK2 is a potential therapeutic target for aggressive prostate tumors.

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Keywords

PCK2 Protein, Human, Recombinant (His & GST) PEPCK-M PEPCK2 phosphoenolpyruvate carboxykinase 2 PEPCK PEPCK 2 mitochondrial phosphoenolpyruvate carboxykinase 2 (mitochondrial) PEPCK-2 recombinant recombinant-proteins proteins protein

 

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