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Ergosta-7,22-dien-3-one

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Catalog No. TN3983Cas No. 32507-77-0

Ergosta-7,22-dien-3-one is a lanosterane that can be isolated from the substrates of Ganoderma taiwanensis. It exhibits pro-inflammatory properties, stimulating nitric oxide production, inducing gene expression, and promoting the production of TLRs, cytokines, chemokines, and cellular adhesion molecules.

Ergosta-7,22-dien-3-one

Ergosta-7,22-dien-3-one

😃Good
Catalog No. TN3983Cas No. 32507-77-0
Ergosta-7,22-dien-3-one is a lanosterane that can be isolated from the substrates of Ganoderma taiwanensis. It exhibits pro-inflammatory properties, stimulating nitric oxide production, inducing gene expression, and promoting the production of TLRs, cytokines, chemokines, and cellular adhesion molecules.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$1,168InquiryInquiry
1 mL x 10 mM (in DMSO)$1,408InquiryInquiry
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Ergosta-7,22-dien-3-one is a lanosterane that can be isolated from the substrates of Ganoderma taiwanensis. It exhibits pro-inflammatory properties, stimulating nitric oxide production, inducing gene expression, and promoting the production of TLRs, cytokines, chemokines, and cellular adhesion molecules.
In vitro
Ergosta-7,22-dien-3-one, isolated from a wild Mexican strain of Ganoderma oerstedii. According study, Ergosta-7,22-dien-3-one did not present any cytotoxic effect on HeLa or J774A.1 cells, and it was able to stimulate nitric oxide production, induce the expression of genes, and induce the production of TLRs, cytokines, chemokines, and cellular adhesion molecules in J774A.1 cells, based on reverse-transcriptase polymerase chain reaction and enzyme-linked immunosorbent assay. Here we report a new pro-inflammatory property of Ergosta-7,22-dien-3-one, which should be considered as a possible adjuvant property in view of its biological activity.[1]
Chemical Properties
Molecular Weight396.65
FormulaC28H44O
Cas No.32507-77-0
SmilesC[C@@]12[C@](C=3[C@@]([C@]4(C)C(CC3)(CC(=O)CC4)[H])(CC1)[H])(CC[C@@]2([C@@H](C=C[C@@H](C(C)C)C)C)[H])[H]
Relative Density.0.99 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
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1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

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Keywords

NOSynthaseNO SynthaseNOLTRErgosta-7,22-dien-3-oneErgosta7,22dien3oneErgosta 7,22 dien 3 one
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