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Levocetirizine

Name: Levocetirizine
Brand: TargetMol
SKU: T1469
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1469Cas No. 130018-77-8

Alias Levocetirizine HCl

Levocetirizine is a Histamine-1 Receptor Antagonist. The mechanism of action of levocetirizine is as a Histamine H1 Receptor Antagonist.

Levocetirizine

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Purity: 99.94%

Catalog No. T1469Alias Levocetirizine HClCas No. 130018-77-8

Levocetirizine is a Histamine-1 Receptor Antagonist. The mechanism of action of levocetirizine is as a Histamine H1 Receptor Antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$32	In Stock	In Stock
10 mg	$57	In Stock	In Stock
25 mg	$82	In Stock	In Stock
50 mg	$97	In Stock	In Stock
100 mg	$182	In Stock	In Stock
200 mg	$271	-	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.94%

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Levocetirizine AI Summary

Levocetirizine exhibits a range of significant bioactivities and pharmacokinetic properties. It acts as an inhibitor of multiple targets with various potencies: JMJD2A-Tudor Domain (89125.1 nM), Histone Lysine Methyltransferase G9a (39810.7 nM), BAZ2B (79432.8 nM), ERG Ets/DNA interaction (7943.3 nM), and USP1/UAF1 (89125.1 nM). Additionally, it functions as a ligand for beta-arrestin-biased ligands of the beta2-adrenergic receptor with a potency of 10000.0 nM, and it induces DNA re-replication in SW480 colon adenocarcinoma cells at a potency of 28183.8 nM. Pharmacokinetically, Levocetirizine displays high plasma protein binding of 85% in both human and guinea pig models and demonstrates a low ratio of unbound drug in the brain to plasma (Kp,uu,brain of 0.14) and a brain to plasma partition coefficient (Kp) of 0.22 in guinea pigs, indicating its limited brain penetration. The compound also exhibits antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells, although the hit score (-0.05445) suggests potential off-disease activity. Moreover, Levocetirizine shows antimicrobial activities, specifically: - Antifungal activity against Candida albicans (0.53% inhibition) and Cryptococcus neoformans (0.71% inhibition) - Antibacterial activity against Escherichia coli (5.57% inhibition), Klebsiella pneumoniae (20.22% inhibition), Pseudomonas aeruginosa (6.8% inhibition), Acinetobacter baumannii (19.94% inhibition), and Staphylococcus aureus MRSA (11.65% inhibition) Lastly, it exhibits inhibitory activity toward human HDAC6, demonstrating slightly stronger inhibition in assays using custom peptide substrates compared to commercial ones..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Levocetirizine is a Histamine-1 Receptor Antagonist. The mechanism of action of levocetirizine is as a Histamine H1 Receptor Antagonist.
Synonyms	Levocetirizine HCl

Chemical Properties

Molecular Weight	388.89
Formula	C₂₁H₂₅ClN₂O₃
Cas No.	130018-77-8
Smiles	[C@H](N1CCN(CCOCC(O)=O)CC1)(C2=CC=C(Cl)C=C2)C3=CC=CC=C3
Relative Density.	1.237g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store under nitrogen | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (57.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5714 mL	12.8571 mL	25.7142 mL	128.5711 mL
5 mM	0.5143 mL	2.5714 mL	5.1428 mL	25.7142 mL
10 mM	0.2571 mL	1.2857 mL	2.5714 mL	12.8571 mL
20 mM	0.1286 mL	0.6429 mL	1.2857 mL	6.4286 mL
50 mM	0.0514 mL	0.2571 mL	0.5143 mL	2.5714 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc