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Ceanothic acid

Name: Ceanothic acid
Brand: TargetMol
SKU: TN1477
Rating: 4.5 (1 reviews)

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Catalog No. TN1477Cas No. 21302-79-4

Ceanothic acid derivatives show cytotoxic effect against OVCAR-3 and HeLa cancer cell lines.

Ceanothic acid

😃Good

Catalog No. TN1477Cas No. 21302-79-4

Ceanothic acid derivatives show cytotoxic effect against OVCAR-3 and HeLa cancer cell lines.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$2,450	Inquiry	Inquiry

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Product Introduction

Bioactivity

Description

Ceanothic acid derivatives show cytotoxic effect against OVCAR-3 and HeLa cancer cell lines.

In vitro

Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from Ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo-Ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 microg/mL, respectively, and an IC50 of 11.3 microg/mL against normal cell line FS-5.

Chemical Properties

Molecular Weight	486.693
Formula	C₃₀H₄₆O₅
Cas No.	21302-79-4
Smiles	[H][C@@]12CC[C@]3(C)[C@]([H])(CC[C@]4([H])[C@@]5([H])[C@@H](CC[C@@]5(CC[C@@]34C)C(O)=O)C(C)=C)[C@@]1(C)[C@H]([C@H](O)C2(C)C)C(O)=O
Relative Density.	1.149 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

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Keywords

Ceanothic acid