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Neurotrophin 3 Protein, Human, Recombinant

(Synonyms: NT-3, NT3, NGF-2, NGF2, neurotrophin 3, HDNF) Copy Product Info

Synonyms: NT-3, NT3, NGF-2, NGF2, neurotrophin 3, HDNF

Catalog No. TMPY-04069 Copy Product Info
NTF3 (Neurotrophin 3) is a Protein Coding gene. The protein encoded by this gene is a member of the neurotrophin family, that controls the survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. NTF3 is a key mediator of neuronal development during the early neurogenic period. NTF3 is a novel target gene of POU3F2 and that the POU3F2/NTF3 pathway plays a role in the process of neuronal differentiation. NTF3 is capable of activating TrkB to induce anoikis resistance, and show that NTF3 is also a direct target of miR-200c. NTF3 is broadly expressed in the ovary, spleen, and other tissues. Diseases associated with NTF3 include Hypochondriasis and Demyelinating Disease.
Pack SizePriceUSA StockGlobal StockQuantity
5 μg$687-10 days7-10 days
10 μg$1087-10 days7-10 days
20 μg$177In StockIn Stock
50 μg$2797-10 days7-10 days
100 μg$3977-10 days7-10 days
200 μg$6797-10 days7-10 days
500 μgPreferential7-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:93.7%
Appearance:Lyophilized powder
Color:White
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Product Introduction

Bioactivity
Bioactivity
Measured by its binding ability in a functional ELISA. Immobilized human NT3 at 2 μg/ml (100 μl/well) can bind human TrkB-Fch . The EC50 of human TrkB-Fch is 120-350 ng/mL.
Neurotrophin 3 Protein, Human, Recombinant
Description
NTF3 (Neurotrophin 3) is a Protein Coding gene. The protein encoded by this gene is a member of the neurotrophin family, that controls the survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. NTF3 is a key mediator of neuronal development during the early neurogenic period. NTF3 is a novel target gene of POU3F2 and that the POU3F2/NTF3 pathway plays a role in the process of neuronal differentiation. NTF3 is capable of activating TrkB to induce anoikis resistance, and show that NTF3 is also a direct target of miR-200c. NTF3 is broadly expressed in the ovary, spleen, and other tissues. Diseases associated with NTF3 include Hypochondriasis and Demyelinating Disease.
Species
Human
Expression System
E. coli
TagTag Free
Accession NumberP20783-1
ConstructionA DNA sequence encoding the human NT3 (P20783-1) (Tyr139-Thr257) was expressed and purified. Predicted N terminal: Met
Protein Purity
> 90 % as determined by SDS-PAGE
Neurotrophin 3 Protein, Human, Recombinant
EndotoxinPlease contact us for more information.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 5. 2. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
ReconstitutionReconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Stability & StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
SynonymsNT-3, NT3, NGF-2, NGF2, neurotrophin 3, HDNF
Research Background
Chemical Properties
Molecular Weight13.8 kDa (predicted); 16 kDa (reducing conditions)
Storage & Solubility Information
StorageLyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months

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Keywords

Related Tags: Neurotrophin 3 Protein, Human, Recombinant chemical structure | Neurotrophin 3 Protein, Human, Recombinant molecular weight