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CCT367766 formic

Catalog No. T77915

CCT367766 formic is a potent third-generation heterobifunctional Cereblon-based protein degradation probe (PDP, or PROTAC) that selectively targets pirin for degradation, effectively diminishing its protein expression at low concentrations. This compound demonstrates moderate affinity towards the CRBN-DDB1 complex, as denoted by an IC50 value of 490 nM, while exhibiting strong binding to recombinant pirin and CRBN, with respective Kd values of 55 nM and 120 nM. As such, CCT367766 formic serves as a valuable chemical probe for investigating the functions of the largely unexplored pirin protein [1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CCT367766 formic, CAS N/A

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Biological Description

Chemical Properties

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Description	CCT367766 formic is a potent third-generation heterobifunctional Cereblon-based protein degradation probe (PDP, or PROTAC) that selectively targets pirin for degradation, effectively diminishing its protein expression at low concentrations. This compound demonstrates moderate affinity towards the CRBN-DDB1 complex, as denoted by an IC50 value of 490 nM, while exhibiting strong binding to recombinant pirin and CRBN, with respective Kd values of 55 nM and 120 nM. As such, CCT367766 formic serves as a valuable chemical probe for investigating the functions of the largely unexplored pirin protein [1].
Targets&IC50	CRBN-DDB1:490 nM
In vitro	CCT367766 formic at concentrations ranging from 50 to 1500 nM over 24 hours exhibits time-dependent diminishment of pirin protein levels, echoing a hook effect in SK-OV-3 human ovarian cancer cells [1]. At lower doses (0.5-50 nM for 2 hours), CCT367766 formic causes a concentration-dependent reduction of pirin protein in these cells [1]. Furthermore, the same dosage range over a 2-hour period can counteract the suppression effect of chlorobisamide pretreatment on pirin protein levels in SK-OV-3 cells [1].

Molecular Weight	992.42
Formula	C50H50ClN7O13

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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PROTAC CDK9 degrader-8 PROTAC TTK degrader-1 PTD10 Tri-GalNAc-DBCO di-Ellipticine-RIBOTAC PROTAC TG2 degrader-1 MS6105 HJM-561

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Keywords

CCT367766 formic PROTAC PROTACs inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.