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Anthopleurin-A

Name: Anthopleurin-A
Brand: TargetMol
SKU: TP2540
Rating: 4.5 (1 reviews)

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Catalog No. TP2540Cas No. 60880-63-9

Anthopleurin-A, a sodium channel toxin, is selective for cardiac channels and has a cardiotonic effect. It can be isolated from the sea anemone [1] [2].

Anthopleurin-A

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Catalog No. TP2540Cas No. 60880-63-9

Anthopleurin-A, a sodium channel toxin, is selective for cardiac channels and has a cardiotonic effect. It can be isolated from the sea anemone [1] [2].

Pack Size	Price	Availability	Quantity
10 mg	Inquiry	Inquiry
50 mg	Inquiry	Inquiry

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Product Introduction

Bioactivity

Description	Anthopleurin-A, a sodium channel toxin, is selective for cardiac channels and has a cardiotonic effect. It can be isolated from the sea anemone [1] [2].
In vitro	Anthopleurin-A (2 nM-640 nM) increases the contractile force of isolated feline papillary muscles [2].
In vivo	Intravenous administration of Anthopleurin-A (0.2 μg/kg/min) enhances myocardial contractility in anesthetized dogs [2].

Chemical Properties

Molecular Weight	5131.72
Formula	C₂₂₀H₃₂₆N₆₄O₆₇S₆
Cas No.	60880-63-9
Sequence	Gly-Val-Ser-Cys-Leu-Cys-Asp-Ser-Asp-Gly-Pro-Ser-Val-Arg-Gly-Asn-Thr-Leu-Ser-Gly-Thr-Leu-Trp-Leu-Tyr-Pro-Ser-Gly-Cys-Pro-Ser-Gly-Trp-His-Asn-Cys-Lys-Ala-His-Gly-Pro-Thr-Ile-Gly-Trp-Cys-Cys-Lys-Gln (Disulfide bridge: Cys4-Cys46,Cys6-Cys36,Cys29- Cys47)
Sequence Short	GVSCLCDSDGPSVRGNTLSGTLWLYPSGCPSGWHNCKAHGPTIGWCCKQ (Disulfide bridge: Cys4-Cys46,Cys6-Cys36,Cys29- Cys47)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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