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Arvanil
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Catalog No. T22586Cas No. 128007-31-8
Alias N-Vanillylarachidonamide
Arvanil (N-Vanillylarachidonamide) is a synthetic capsaicin-amphetamine hybrid and a ligand for vanilloid receptor 1 (VR1) and cannabinoid receptor 1 (CB1), exhibiting neuroprotective activity, inhibiting spasm, and enhancing cisplatin chemotherapy sensitivity by inducing ferroptosis in HCC cells in vivo. It induces ferroptosis in liver cancer cells via binding to MICU1.
Arvanil
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Purity: 99.49%
Catalog No. T22586Alias N-VanillylarachidonamideCas No. 128007-31-8
Arvanil (N-Vanillylarachidonamide) is a synthetic capsaicin-amphetamine hybrid and a ligand for vanilloid receptor 1 (VR1) and cannabinoid receptor 1 (CB1), exhibiting neuroprotective activity, inhibiting spasm, and enhancing cisplatin chemotherapy sensitivity by inducing ferroptosis in HCC cells in vivo. It induces ferroptosis in liver cancer cells via binding to MICU1.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $85 | - | In Stock | |
| 10 mg | $160 | - | In Stock | |
| 50 mg | $660 | - | In Stock | |
| 100 mg | $1,140 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.49%
Appearance:Oil
Color:Transparent
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Arvanil (N-Vanillylarachidonamide) is a synthetic capsaicin-amphetamine hybrid and a ligand for vanilloid receptor 1 (VR1) and cannabinoid receptor 1 (CB1), exhibiting neuroprotective activity, inhibiting spasm, and enhancing cisplatin chemotherapy sensitivity by inducing ferroptosis in HCC cells in vivo. It induces ferroptosis in liver cancer cells via binding to MICU1. |
| In vitro | Arvanil directly binds to two amino acid sites of mitochondrial calcium uptake protein 1 (MICU1), Ser47 and Phe128, triggering iron death in living cells. [1] Arvanil inhibits lymphocyte proliferation and IFN-γ production. Phenotypes of activated CD4+T cells treated with Arvanil showed downregulation of T cell activation markers such as CD25, HLA-DR, and CD134/OX40. [2] |
| In vivo | Arvanil (2 mg/kg, intrabitoneally injected) induced anti-hyperkinetic state in rats injected with 3-nitropropionic acid (3-NP) in bilateral striatum. [3] |
| Synonyms | N-Vanillylarachidonamide |
| Molecular Weight | 439.63 |
| Formula | C28H41NO3 |
| Cas No. | 128007-31-8 |
| Smiles | C(NC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)C1=CC(OC)=C(O)C=C1 |
| Relative Density. | 1.31g/cm3 |
| Storage | store at low temperature,High Volatility | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | Ethanol: 8 mg/mL (18.2 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
Ethanol
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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