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(Z)-KC02

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Catalog No. T78594Cas No. 1646795-60-9

(Z)-KC02 is an ABHD16A inhibitor which targets the enzyme responsible for producing lysophosphatidylserine (lyso-PS), a lipid involved in regulating immune and neurological functions. This compound is linked to the mitigation of neurological disorders, including retinitis pigmentosa and cataracts (PHARC), by depleting lyso-PS in lymphoblasts from affected individuals. Moreover, (Z)-KC02 diminishes lyso-PS levels and lipopolysaccharide-induced cytokine production in macrophages and influences lyso-PS metabolism in vivo [1].

(Z)-KC02

(Z)-KC02

😃Good
Catalog No. T78594Cas No. 1646795-60-9
(Z)-KC02 is an ABHD16A inhibitor which targets the enzyme responsible for producing lysophosphatidylserine (lyso-PS), a lipid involved in regulating immune and neurological functions. This compound is linked to the mitigation of neurological disorders, including retinitis pigmentosa and cataracts (PHARC), by depleting lyso-PS in lymphoblasts from affected individuals. Moreover, (Z)-KC02 diminishes lyso-PS levels and lipopolysaccharide-induced cytokine production in macrophages and influences lyso-PS metabolism in vivo [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
100 μg$15935 days35 days
500 μg$66335 days35 days
1 mg$1,08035 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
(Z)-KC02 is an ABHD16A inhibitor which targets the enzyme responsible for producing lysophosphatidylserine (lyso-PS), a lipid involved in regulating immune and neurological functions. This compound is linked to the mitigation of neurological disorders, including retinitis pigmentosa and cataracts (PHARC), by depleting lyso-PS in lymphoblasts from affected individuals. Moreover, (Z)-KC02 diminishes lyso-PS levels and lipopolysaccharide-induced cytokine production in macrophages and influences lyso-PS metabolism in vivo [1].
In vitro
(Z)-KC02 disrupts ABHD16A in murine macrophages, thereby reducing lyso-PS levels [1].
Chemical Properties
Molecular Weight287.35
FormulaC17H21NO3
Cas No.1646795-60-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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