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E3 ligase Ligand 18 is a small molecule ligand that specifically binds to E3 ubiquitin ligase, and E3 ligase Ligand 18 can be chemically linked to a protein-targeting ligand through a molecular linker to construct proteolysis-targeting chimeras (PROTACs), which subsequently induce ubiquitination-mediated degradation of disease-related proteins such as oncogenic factors, thereby supporting the study of targeted protein degradation in cancer biology.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $55 | In Stock | |
5 mg | $129 | In Stock | |
10 mg | $198 | In Stock | |
25 mg | $413 | In Stock | |
50 mg | $668 | In Stock | |
100 mg | $1,070 | In Stock |
Description | E3 ligase Ligand 18 is a small molecule ligand that specifically binds to E3 ubiquitin ligase, and E3 ligase Ligand 18 can be chemically linked to a protein-targeting ligand through a molecular linker to construct proteolysis-targeting chimeras (PROTACs), which subsequently induce ubiquitination-mediated degradation of disease-related proteins such as oncogenic factors, thereby supporting the study of targeted protein degradation in cancer biology. |
Synonyms | E3 ligase Ligand18 |
Molecular Weight | 436.87 |
Formula | C17H17ClN6O4S |
Cas No. | 2241669-88-3 |
Smiles | C(N1C2=C(N=C1SC[C@H](NC(C)=O)C(O)=O)C(=O)N=C(N)N2)C3=CC=C(Cl)C=C3 |
Relative Density. | 1.68 g/cm3 (Predicted) |
Color | White |
Appearance | Solid |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
Solubility Information | DMSO: 20 mg/mL (45.78 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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