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E3 ligase Ligand 18

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Catalog No. T17876Cas No. 2241669-88-3
Alias E3 ligase Ligand18

E3 ligase Ligand 18 is a small molecule ligand that specifically binds to E3 ubiquitin ligase, and E3 ligase Ligand 18 can be chemically linked to a protein-targeting ligand through a molecular linker to construct proteolysis-targeting chimeras (PROTACs), which subsequently induce ubiquitination-mediated degradation of disease-related proteins such as oncogenic factors, thereby supporting the study of targeted protein degradation in cancer biology.

E3 ligase Ligand 18

E3 ligase Ligand 18

🥰Excellent
Purity: 98.125%
Catalog No. T17876Alias E3 ligase Ligand18Cas No. 2241669-88-3
E3 ligase Ligand 18 is a small molecule ligand that specifically binds to E3 ubiquitin ligase, and E3 ligase Ligand 18 can be chemically linked to a protein-targeting ligand through a molecular linker to construct proteolysis-targeting chimeras (PROTACs), which subsequently induce ubiquitination-mediated degradation of disease-related proteins such as oncogenic factors, thereby supporting the study of targeted protein degradation in cancer biology.
Pack SizePriceAvailabilityQuantity
1 mg$55In Stock
5 mg$129In Stock
10 mg$198In Stock
25 mg$413In Stock
50 mg$668In Stock
100 mg$1,070In Stock
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Purity:98.125%
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Product Introduction

Bioactivity
Description
E3 ligase Ligand 18 is a small molecule ligand that specifically binds to E3 ubiquitin ligase, and E3 ligase Ligand 18 can be chemically linked to a protein-targeting ligand through a molecular linker to construct proteolysis-targeting chimeras (PROTACs), which subsequently induce ubiquitination-mediated degradation of disease-related proteins such as oncogenic factors, thereby supporting the study of targeted protein degradation in cancer biology.
SynonymsE3 ligase Ligand18
Chemical Properties
Molecular Weight436.87
FormulaC17H17ClN6O4S
Cas No.2241669-88-3
SmilesC(N1C2=C(N=C1SC[C@H](NC(C)=O)C(O)=O)C(=O)N=C(N)N2)C3=CC=C(Cl)C=C3
Relative Density.1.68 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 20 mg/mL (45.78 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2890 mL11.4451 mL22.8901 mL114.4505 mL
5 mM0.4578 mL2.2890 mL4.5780 mL22.8901 mL
10 mM0.2289 mL1.1445 mL2.2890 mL11.4451 mL
20 mM0.1145 mL0.5723 mL1.1445 mL5.7225 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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