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Mgc(3Me)FDA

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Catalog No. T86895Cas No. 2763442-01-7

Mgc(3Me)FDA, a derivative of fluorescein diacetate (FDA) that incorporates a cell-permeable myrGC 3Me motif, effectively penetrates cells. Once inside, it transforms into the fluorescently active mgc(3Me)FL. This compound specifically accumulates in the Golgi apparatus, serving as a visualized Golgi probe [1].

Mgc(3Me)FDA

Mgc(3Me)FDA

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Catalog No. T86895Cas No. 2763442-01-7
Mgc(3Me)FDA, a derivative of fluorescein diacetate (FDA) that incorporates a cell-permeable myrGC 3Me motif, effectively penetrates cells. Once inside, it transforms into the fluorescently active mgc(3Me)FL. This compound specifically accumulates in the Golgi apparatus, serving as a visualized Golgi probe [1].
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
Mgc(3Me)FDA, a derivative of fluorescein diacetate (FDA) that incorporates a cell-permeable myrGC 3Me motif, effectively penetrates cells. Once inside, it transforms into the fluorescently active mgc(3Me)FL. This compound specifically accumulates in the Golgi apparatus, serving as a visualized Golgi probe [1].
In vitro
mgc(3Me)FDA, when applied at 10 μM for 10 minutes to HeLa cells, localizes with the Golgi apparatus around the cell nucleus and exhibits green fluorescence [1]. At a concentration of 2.5 μM for 30-270 minutes, mgc(3Me)FDA allows visualization of dynamic morphological changes in the Golgi apparatus during Brefeldin A-induced disassembly in live HeLa cells [1]. Immunofluorescence studies conducted on human epithelial HeLa cells showed fluorescence mainly in the perinuclear Golgi region, co-localizing with the Golgi-tagged fluorescent protein mCherry-Giantin at a concentration of 10 μM for an incubation time of 10 minutes.
Chemical Properties
Molecular Weight1145.36
FormulaC59H80N6O15S
Cas No.2763442-01-7
SmilesO=C1OC2(C=3C1=CC(C(NCCCC[C@H](NC(COCCOCCN(C([C@@H](N(C(CN(C(CCCCCCCCCCCCC)=O)C)=O)C)CS)=O)C)=O)C(N)=O)=O)=CC3)C=4C(OC=5C2=CC=C(OC(C)=O)C5)=CC(OC(C)=O)=CC4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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