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Gardenin A

Name: Gardenin A
Brand: TargetMol
SKU: TN4114
Price: 189 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN4114 Copy Product Info

Purity: 99.98%

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Gardenin A is a synthetic polymethoxyflavone (PMF) analog with oral efficacy. It exerts neurotrophic effects by activating the MAPK/ERK, PKC, and PKA pathways, and possesses antidepressant, anxiolytic, and anticonvulsant activities.

Cas No. 21187-73-5

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Pack Size	Price	USA Stock	Global Stock
1 mg	$189	In Stock	In Stock
5 mg	$479	In Stock	In Stock
10 mg	$687	In Stock	In Stock
25 mg	$1,050	In Stock	In Stock
50 mg	$1,390	In Stock	In Stock
100 mg	$1,890	-	In Stock
1 mL x 10 mM (in DMSO)	$529	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.98%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Gardenin A is a synthetic polymethoxyflavone (PMF) analog with oral efficacy. It exerts neurotrophic effects by activating the MAPK/ERK, PKC, and PKA pathways, and possesses antidepressant, anxiolytic, and anticonvulsant activities.
Targets & IC50	colon cancer cells (human):> 100 μM, HL-60 cells:> 100 μM
In vitro	Oral administratGardenin A (25 mg/kg) shows sedative effects and increases the duration of sleep without altering sleep onset[2].
In vivo	Methods: Male Balb/c mice were used. Gardenin A was administered orally as a single dose at 0.1–25 mg/kg, dissolved in 0.5% carboxymethyl cellulose-normal saline, with behavioral tests conducted 1 hour after administration. Results:25 mg/kg prolonged pentobarbital-induced sleep time; 1–25 mg/kg showed anxiolytic-like effects in elevated plus maze, light-dark box, exploratory cylinder, and open field tests (ED₅₀=7 mg/kg), and dose-dependently reduced immobility time in tail suspension and forced swimming tests (ED₅₀=3–6 mg/kg). [1] Methods: A53T α-synuclein transgenic mouse model was used. Gardenin A was administered orally by gavage at doses of 25 or 100 mg/kg, three times per week for 4 consecutive weeks, dissolved in 0.5% carboxymethyl cellulose-normal saline. Results: The 100 mg/kg dose significantly improved conditioned fear memory, open field locomotor activity, and gait abnormalities in mice, reduced brain phosphorylated α-synuclein levels, and restored striatal tyrosine hydroxylase expression. [2]

Chemical Properties

Molecular Weight	418.39
Formula	C₂₁H₂₂O₉
Cas No.	21187-73-5
Smiles	O(C)C1=C2C(=C(O)C(OC)=C1OC)C(=O)C=C(O2)C3=CC(OC)=C(OC)C(OC)=C3
Relative Density.	1.300 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 21.6 mg/mL (51.63 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3901 mL	11.9506 mL	23.9011 mL	119.5057 mL
5 mM	0.4780 mL	2.3901 mL	4.7802 mL	23.9011 mL
10 mM	0.2390 mL	1.1951 mL	2.3901 mL	11.9506 mL
20 mM	0.1195 mL	0.5975 mL	1.1951 mL	5.9753 mL
50 mM	0.0478 mL	0.2390 mL	0.4780 mL	2.3901 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.