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Gardenin A

Name: Gardenin A
Brand: TargetMol
SKU: TN4114
Price: 197 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN4114Cas No. 21187-73-5

Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.

Gardenin A

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Purity: 99.98%

Catalog No. TN4114Cas No. 21187-73-5

Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.

Pack Size	Price	Availability
1 mg	$197	In Stock
5 mg	$491	In Stock
10 mg	$730	In Stock
25 mg	$1,130	In Stock
50 mg	$1,530	In Stock
100 mg	$1,980	In Stock
500 mg	$4,130	Backorder
1 mL x 10 mM (in DMSO)	$529	In Stock

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Purity:99.98%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
Targets&IC50	HL-60 cells:> 100 μM, colon cancer cells (human):> 100 μM
In vitro	Oral administratGardenin A (25 mg/kg) shows sedative effects and increases the duration of sleep without altering sleep onset[2].

Chemical Properties

Molecular Weight	418.39
Formula	C₂₁H₂₂O₉
Cas No.	21187-73-5
Smiles	O(C)C1=C2C(=C(O)C(OC)=C1OC)C(=O)C=C(O2)C3=CC(OC)=C(OC)C(OC)=C3
Relative Density.	1.300 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 21.6 mg/mL (51.63 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3901 mL	11.9506 mL	23.9011 mL	119.5057 mL
5 mM	0.4780 mL	2.3901 mL	4.7802 mL	23.9011 mL
10 mM	0.2390 mL	1.1951 mL	2.3901 mL	11.9506 mL
20 mM	0.1195 mL	0.5975 mL	1.1951 mL	5.9753 mL
50 mM	0.0478 mL	0.2390 mL	0.4780 mL	2.3901 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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