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RBP4 Protein, Human, Recombinant (His)

TargetMol | SPR
Catalog No. TMPY-00907

RBP4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23 kDa and the accession number is P02753.

RBP4 Protein, Human, Recombinant (His)

RBP4 Protein, Human, Recombinant (His)

TargetMol | SPR
Catalog No. TMPY-00907
RBP4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23 kDa and the accession number is P02753.
Pack SizePriceAvailabilityQuantity
5 μg$487-10 days
10 μg$757-10 days
20 μg$1187-10 days
50 μg$2297-10 days
100 μg$386In Stock
200 μg$6607-10 days
500 μg$1,3307-10 days
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Product Information

Biological Activity
Measured by its ability to bind all-trans retinoic acid. The binding of retinoic acid results in the quenching of Trp fluorescence in RBP4. The 50% binding concentration (BC50) is > 1.0 µM.
Description
RBP4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23 kDa and the accession number is P02753.
Species
Human
Expression System
HEK293 Cells
TagC-His
Accession NumberP02753
Synonyms
retinol binding protein 4, plasma,RDCCAS
Construction
A DNA sequence encoding the pro form of human RBP4 (NP_006735.2) (Met 1-Leu 201) was expressed with a C-terminal polyhistidine tag. Predicted N terminal: Glu 19
Protein Purity
≥ 85 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
RBP4 Protein, Human, Recombinant (His)RBP4 Protein, Human, Recombinant (His)
Molecular Weight23 kDa (predicted)
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.2. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice.
Research Background
Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A), and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex in plasma through their tight interaction. As a member of the lipocalin superfamily, RBP4 containing a β-barrel structure with a well-defined cavity is secreted from the liver, and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), and this binding is crucial for preventing RBP4 excretion through the kidney glomeruli. RBP4 expressed from an ectopic source efficiently delivers retinol to the eyes, and its deficiency affects night vision largely. Recently, RBP4 as an adipokine, is found to be expressed in adipose tissue and correlated with obesity, insulin resistance (IR) and type 2 diabetes (T2DM).

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Please read the User Guide of Recombinant Proteins for more specific information.